Dephosphorylation of Psilocybin to Psilocin by Alkaline Phosphatase
Experimental Biology and Medicine 1961 DOI: 10.3181/00379727-106-26228 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Laboratory experiment Peer reviewed |
|---|---|
| Topics | Psilocybin |
| Keywords | Dephosphorylation Alkaline phosphatase Hallucinogen Biochemistry |
| Citations | 49 |
| Key findings | Intestinal phosphatase dephosphorylates psilocybin to produce psilocin and inorganic phosphate. |
Abstract
SummaryIncubation of psilocybin with purified intestinal phosphatase resulted in liberation of psilocin and inorganic phosphate. Psilocin formed was determined both quantitatively by a specific colorimetric method employing the nitrosonaphthol reagent and qualitatively by paper chromatography. Some characteristics of the phosphatase action on psilocybin are described. The possibility of a similar reaction occurring in the intact animal is discussed.
Comparable studies
Other experimental studies on psilocybin, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Psilocybin induces schizophrenia-like psychosis in humans via a serotonin-2 agonist action Healthy human volunteers | 1998 | Experimental study | |
| Validation of the revised Mystical Experience Questionnaire in experimental sessions with psilocybin Participants in controlled laboratory experiments receiving a moderate to high oral... | 2015 | Validation study using pooled data from five laboratory experiments | n = 184 |
| Broadband Cortical Desynchronization Underlies the Human Psychedelic State Healthy human participants | 2013 | Experimental study | |
| Long-term follow-up of psilocybin-assisted psychotherapy for psychiatric and existential distress in patients with life-threatening cancer Participants with cancer-related psychiatric distress who completed a parent randomized... | 2020 | Long-term within-subjects follow-up analysis | n = 15 |
| Enzymatic Synthesis of Psilocybin | 2017 | Laboratory study |
Citations in the library
Cited by 32
- Psilocybin – Summary of knowledge and new perspectives European Neuropsychopharmacology December 17, 2013
- Differential contributions of serotonin receptors to the behavioral effects of indoleamine hallucinogens in mice Journal of Psychopharmacology December 8, 2010
- Investigation of the Structure–Activity Relationships of Psilocybin Analogues ACS Pharmacology & Translational Science December 14, 2020
- Structure–Activity Relationships for Psilocybin, Baeocystin, Aeruginascin, and Related Analogues to Produce Pharmacological Effects in Mice ACS Pharmacology & Translational Science November 2, 2022
- Psilocybin-induced stimulus control in the rat. Pharmacology, Biochemistry, and Behavior October 1, 2007
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