Synergism of Amines and Antagonism of Reserpine to Morphine Analgesia
E. B. Sigg, G. Caprio, J. A. Schneider
Experimental Biology and Medicine 1958 DOI: 10.3181/00379727-97-23656 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Mice |
| Interventions | Reserpine morphine meperidine codeine 5-hydroxytryptamine tryptamine amphetamine mescaline epinephrine iproniazid choline-p-tolyl-ether |
| Topics | Mescaline |
| Keywords | Reserpine Morphine Iproniazid Pharmacology Codeine Tryptamine Antagonism Amphetamine Anesthesia |
| Citations | 78 |
| Key findings | Reserpine antagonizes morphine, meperidine, and codeine analgesia in mice, while several amines prolong and enhance morphine analgesia. |
Abstract
(1) Reserpine antagonizes the analgesia in mice induced by morphine, meperidine and codeine. (2) Five-hydroxytryptophane, 5-hydroxytryptamine, tryptamine, amphetamine, mescaline and epinephrine prolong and enhance morphine analgesia whereas iproniazid and choline-p-tolyl-ether fail to do so. (3) Possible mechanisms involved in the synergistic action of amines and the antagonistic action of reserpine on morphine analgesia are discussed.
Comparable studies
Other preclinical and animal studies on mescaline, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Correlation between the potency of hallucinogens in the mouse head-twitch response assay and their behavioral and subjective effects in other species. C57BL/6J mice | 2020 | Experimental study with dose-response experiments | |
| Brain mechanisms of hallucinogens and entactogens Humans and rats | 2001 | Review | |
| Effects of hallucinogenic agents mescaline and phencyclidine on zebrafish behavior and physiology Zebrafish (Danio rerio) | 2012 | Experimental study | |
| Lysergic Acid Diethylamide- and Mescaline-Induced Attenuation of the Effect of Punishment in the Rat Rats | 1976 | Experimental study | |
| Dihydrobenzofuran Analogues of Hallucinogens. 3. Models of 4-Substituted (2,5-Dimethoxyphenyl)alkylamine Derivatives with Rigidified Methoxy Groups Rats (trained to discriminate saline from LSD tartrate) and rat cortical and... | 1996 | In vivo drug discrimination assay and in vitro radioligand binding assay |