Effects of Hallucinogenic and Tranquilizing Drugs on Serotonin Evoked Uterine Contractions.
Experimental Biology and Medicine 1956 DOI: 10.3181/00379727-91-22163 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Uterus of spayed rat |
| Interventions | Frenquel chlorpromazine reserpine mescaline LSD atropine |
| Topics | LSD Mescaline Serotonin |
| Keywords | Chlorpromazine Reserpine Uterus Oxytocin Atropine Pharmacology Endocrinology Serotonin antagonists Hallucinogen Antagonism Uterine contraction |
| Citations | 64 |
| Key findings | Tranquilizing drugs antagonize serotonin-induced uterine contractions, while mescaline facilitates serotonin activity, and LSD shows dose-dependent dual effects—antagonism at high concentrations and facilitation at low concentrations. |
Abstract
SummaryTranquilizing drugs: Frenquel (0.8 mg/1), chlorpromazine (0.1 mg/1) and reserpine (0.4 mg/1), antagonize serotonin-induced uterine contractions, though they do not affect sensitivity of the uterus of the spayed rat either to ACh or oxytocin. The period of antagonism is longer lasting with reserpine than with chlorpromazine and is shortest with Frenquel. Mescaline (0.1 mg/1) causes a facilitation of serotonin activity, and in highest amounts causes a uterine contraction by itself. However, it is not antagonized by atropine (0.24 mg/1). A relatively high concentration of LSD (1 γ/1) antagonizes both serotonin and mescaline-induced uterine activity. In contrast low concentrations of LSD (0.05 to 0.2 γ/1) facilitate the effects of serotonin and of mescaline on the rat uterus.