The major question posed in this report is whether chronic schizophrenics show less psychologic response to the administration of a given dosage of lysergic acid diethylamide (LSD-25) than do normal adults. Data relevant to this question are of importance in at least three ways: (1) they are of relevance in delineating the mechanism of action of LSD insofar as such mechanisms—whether...
A series of 15 steroid hormones and metabolites were tested for their effectiveness to suppress LSD-25 induced behavior changes in rats. All produced significant suppression (p<0.05) except estradiol. Ability to suppress LSD-25 action does not appear to be related to specific molecular groups or to hormonal potency.