Research published in Neuroscience & Biobehavioral Reviews (page 4)

Functional imaging studies of acute administration of classic psychedelics, ketamine, and MDMA: Methodological limitations and convergent results.

Neuroscience & Biobehavioral Reviews November 1, 2023 Sophia Linguiti, Jacob W Vogel, Valerie J Sydnor et al. 15 citations

Functional magnetic resonance imaging (fMRI) is increasingly used to non-invasively study the acute impact of psychedelics on the human brain. While fMRI is a promising tool for measuring brain function in response to psychedelics, it also has known methodological challenges. We conducted a systematic review of fMRI studies examining acute responses to experimentally administered psychedelics...

DOI: 10.1016/j.neubiorev.2023.105421 Full text Ketamine LSD MDMA Psilocybin +8

A construct-first approach to consciousness science.

Neuroscience & Biobehavioral Reviews November 1, 2023 Peter Fazekas, Axel Cleeremans, Morten Overgaard

We propose a new approach to consciousness science that instead of comparing complex theoretical positions deconstructs existing theories, takes their central assumptions while disregarding their auxiliary hypotheses, and focuses its investigations on the main constructs that these central assumptions rely on (like global workspace, recurrent processing, metarepresentation). Studying how these...

DOI: 10.1016/j.neubiorev.2023.105480 Full text

The zebrafish for preclinical psilocybin research.

Neuroscience & Biobehavioral Reviews October 1, 2023 Omer A. Syed, Benjamin Tsang, Robert Gerlai 7 citations

In this review, we discuss the possible utility of zebrafish in research on psilocybin, a psychedelic drug whose recreational use as well as possible clinical application are gaining increasing interest. First, we review behavioral tests with zebrafish, focussing on anxiety and social behavior, which have particular relevance in the context of psilocybin research. Next, we briefly consider...

DOI: 10.1016/j.neubiorev.2023.105381 Full text Anxiety Psilocybin Affective disorders Social behavior +9

Insight and the selection of ideas.

Neuroscience & Biobehavioral Reviews October 1, 2023 Ruben Laukkonen, Margaret Webb, Carola Salvi et al.

Perhaps it is no accident that insight moments accompany some of humanity's most important discoveries in science, medicine, and art. Here we propose that feelings of insight play a central role in (heuristically) selecting an idea from the stream of consciousness by capturing attention and eliciting a sense of intuitive confidence permitting fast action under uncertainty. The mechanisms...

DOI: 10.1016/j.neubiorev.2023.105363 Full text

The relationship between the default mode network and the theory of mind network as revealed by psychedelics - A meta-analysis.

Neuroscience & Biobehavioral Reviews September 1, 2023 Carla Soares, Gerardo Gonzalo, João Castelhano et al.

The Default Mode Network (DMN) and the Theory of Mind (ToM) networks play a crucial role in our understanding of the neurocognition of the self. The DMN is commonly associated with introspection, while the ToM is involved in perspective-taking. There is no research investigating the overlap between the DMN and ToM in relation to causal effects such as induced by psychedelics, and their precise...

DOI: 10.1016/j.neubiorev.2023.105325 Full text Default mode network Meta-analysis Psychedelics Theory of mind

What is the intention to move and when does it occur?

Neuroscience & Biobehavioral Reviews August 2023 Antonio I Triggiani, Gabriel Kreiman, Cara C Lewis et al.

In 1983 Benjamin Libet and colleagues published a paper apparently challenging the view that the conscious intention to move precedes the brain's preparation for movement. The experiment initiated debates about the nature of intention, the neurophysiology of movement, and philosophical and legal understanding of free will and moral responsibility. Here we review the concept of "conscious...

DOI: 10.1016/j.neubiorev.2023.105199 Full text Bereitschaftspotential Consciousness Free will Intention +2

Understanding visual hallucinations: A new synthesis.

Neuroscience & Biobehavioral Reviews July 1, 2023 Daniel Collerton, James Barnes, Nico J Diederich et al. 80 citations

Despite decades of research, we do not definitively know how people sometimes see things that are not there. Eight models of complex visual hallucinations have been published since 2000, including Deafferentation, Reality Monitoring, Perception and Attention Deficit, Activation, Input, and Modulation, Hodological, Attentional Networks, Active Inference, and Thalamocortical Dysrhythmia Default...

DOI: 10.1016/j.neubiorev.2023.105208 Full text Anomalous experiences Charles bonnet syndrome Eye disease Lewy body +5

The acute effects of psychoactive drugs on emotional episodic memory encoding, consolidation, and retrieval: A comprehensive review.

Neuroscience & Biobehavioral Reviews July 1, 2023 Manoj K. Doss, Harriet de Wit, David A Gallo 30 citations

Psychoactive drugs modulate learning and emotional processes in ways that could impact their recreational and medical use. Recent work has revealed how drugs impact different stages of processing emotional episodic memories, specifically encoding (forming memories), consolidation (stabilizing memories), and retrieval (accessing memories). Drugs administered before encoding may preferentially...

DOI: 10.1016/j.neubiorev.2023.105188 Full text Ketamine MDMA THC Alcohol +13

Relating different dimensions of bodily experiences: Review and proposition of an integrative model relying on phenomenology, predictive brain and neuroscience of the self.

Neuroscience & Biobehavioral Reviews May 1, 2023 Lisa Raoul, Marie-Hélène Grosbras 15 citations

How we mentally experience our body has been studied in a variety research domains. Each of these domains focuses in its own ways on different aspects of the body, namely the neurophysiological, perceptual, affective or social components, and proposes different conceptual taxonomies. It is therefore difficult to find one's way through this vast literature and to grasp the relationships between...

DOI: 10.1016/j.neubiorev.2023.105141 Full text Bodily self-consciousness Body Phenomenal consciousness

Topographic-dynamic reorganisation model of dreams (TRoD) - A spatiotemporal approach.

Neuroscience & Biobehavioral Reviews May 1, 2023 Georg Northoff, Andrea Scalabrini, Stuart Fogel 13 citations

Dreams are one of the most bizarre and least understood states of consciousness. Bridging the gap between brain and phenomenology of (un)conscious experience, we propose the Topographic-dynamic Re-organization model of Dreams (TRoD). Topographically, dreams are characterized by a shift towards increased activity and connectivity in the default-mode network (DMN) while they are reduced in the...

DOI: 10.1016/j.neubiorev.2023.105117 Full text Dream Dynamic Re-organization Self +2

Theories of consciousness and psychiatric disorders – A comparative analysis

Neuroscience & Biobehavioral Reviews April 29, 2023 Riccardo Stefanelli 11 citations

Disorders of consciousness represent an efficient way to test theories of consciousness' (ToCs) predictions. So far, ToCs have mostly focused on disorders of quantitative awareness such as coma, vegetative state, spatial neglect and hemianopia. Psychiatric disorders, by contrast, have received little attention, leaving their contribution to consciousness research almost unexplored. Therefore,...

DOI: 10.1016/j.neubiorev.2023.105204

Sleep and dreaming in the light of reactive and predictive homeostasis.

Neuroscience & Biobehavioral Reviews April 1, 2023 Péter Simor, Philippe Peigneux, Róbert Bódizs

Dreams are often viewed as fascinating but irrelevant mental epihenomena of the sleeping mind with questionable functional relevance. Despite long hours of oneiric activity, and high individual differences in dream recall, dreams are lost into oblivion. Here, we conceptualize dreaming and dream amnesia as inherent aspects of the reactive and predictive homeostatic functions of sleep. Mental...

DOI: 10.1016/j.neubiorev.2023.105104 Full text Dreaming Homeostasis Memory Mind-wandering +2

Utility of preclinical models in the study of psilocybin – A comprehensive review

Neuroscience & Biobehavioral Reviews January 13, 2023 Megan Pedicini, Zachary A. Cordner 13 citations

Interest in the therapeutic potential of psilocybin across a broad range of neuropsychiatric disorders is rapidly expanding. Despite promising clinical data and tremendous public enthusiasm, complimentary basic and translational studies - which are critical for advancing our understanding of psilocybin's biological effects and promoting innovation - have been relatively few. As with all work...

DOI: 10.1016/j.neubiorev.2023.105046 Psilocybin Preclinical models Rodent models Translational neuroscience +7

First few seconds for flow: A comprehensive proposal of the neurobiology and neurodynamics of state onset.

Neuroscience & Biobehavioral Reviews December 1, 2022 Steven Kotler, Michael Mannino, Scott Kelso et al. 44 citations

Flow is a cognitive state that manifests when there is complete attentional absorption while performing a task. Flow occurs when certain internal as well as external conditions are present, including intense concentration, a sense of control, feedback, and a balance between the challenge of the task and the relevant skillset. Phenomenologically, flow is accompanied by a loss of...

DOI: 10.1016/j.neubiorev.2022.104956 Full text Altered consciousness Flow Network neuroscience Systems neuroscience

Cannabinoid treatments for anxiety: A systematic review and consideration of the impact of sleep disturbance.

Neuroscience & Biobehavioral Reviews December 2022 Andrea J Narayan, Luke A. Downey, Brooke Manning et al.

Cannabidiol's (CBD) safety profile and broad action has made it a popular treatment option for anxiety and co-occurring sleep disturbance. However, its efficacy in healthy and clinical populations, treatment duration, formulation and doses for optimal therapeutic benefits remains unclear. Selected databases were examined from inception to October 2022. Study selection, data extraction and...

DOI: 10.1016/j.neubiorev.2022.104941 Full text Anxiety Cannabidiol Cannabinoids Sleep disturbance

Towards characterizing the canonical computations generating phenomenal experience.

Neuroscience & Biobehavioral Reviews November 1, 2022 Megan A. K. Peters

Science and philosophy have long struggled with how to even begin studying the neural or computational basis of qualitative experience. Here I review psychological, neuroscience, and philosophical literature to reveal how perceptual metacognition possesses five unique properties that provide a powerful opportunity for studying the neural and computational correlates of subjective experience:...

DOI: 10.1016/j.neubiorev.2022.104903 Full text Phenomenology Computational modeling Consciousness Metacognition +1

The neuroprotective and neuroplastic potential of glutamatergic therapeutic drugs in bipolar disorder.

Neuroscience & Biobehavioral Reviews November 2022 R Guglielmo, G Hasler

The monoamine hypothesis has dominated research on the pathophysiology of mood disorders as well as the development of therapeutic drugs by over half a century. Nowadays a change of perspective is taking place. The glutamate system is increasingly implicated in the pathophysiology of mood disorders. The evidence spans from animal, post-mortem, imaging, pharmacological and genome-wide...

DOI: 10.1016/j.neubiorev.2022.104906 Full text Ketamine Neuroplasticity Bipolar disorder Glutamate +3

From brain-body function to conscious interactions.

Neuroscience & Biobehavioral Reviews October 2022 Camilo Miguel Signorelli, Joaquin Diaz Boils, Enzo Tagliazucchi et al.

In this review, we discuss empirical results inspiring the introduction of a formal mathematical multilayer model for the biological neuroscience of conscious experience. First, we motivate the discussion through evidence regarding the dynamic brain. Second, we review different brain-body couplings associated with conscious experience and its potential role in driving brain dynamics. Third, we...

DOI: 10.1016/j.neubiorev.2022.104833 Full text Brain Concious experience Consciousness Criticality +3

Focused attention meditation in healthy adults: A systematic review and meta-analysis of cross-sectional functional MRI studies.

Neuroscience & Biobehavioral Reviews October 1, 2022 Saampras Ganesan, Emillie Beyer, Bradford A. Moffat et al.

Meditation trains the mind to focus attention towards an object or experience. Among different meditation techniques, focused attention meditation is considered foundational for more advanced practices. Despite renewed interest in its functional neural correlates, there is no unified neurocognitive model of focused attention meditation developed via quantitative synthesis of contemporary...

DOI: 10.1016/j.neubiorev.2022.104846 Full text Meditation Activation likelihood estimation Focused attention Functional MRI +4

Pharmacological, neural, and psychological mechanisms underlying psychedelics: a critical review

Neuroscience & Biobehavioral Reviews September 1, 2022 Michiel van Elk, David Bryce Yaden 214 citations

This paper provides a critical review of several possible mechanisms at different levels of analysis underlying the effects and therapeutic potential of psychedelics. At the (1) biochemical level, psychedelics primarily affect the 5-HT2A receptor, increase neuroplasticity, offer a critical period for social reward learning, and have anti-inflammatory properties. At the (2) neural level,...

DOI: 10.1016/j.neubiorev.2022.104793 Full text Psychedelics Compounds Hallucinogens Entheogens +19

A voice without a mouth no more: The neurobiology of language and consciousness.

Neuroscience & Biobehavioral Reviews September 1, 2022 Jeremy I Skipper

Most research on the neurobiology of language ignores consciousness and vice versa. Here, language, with an emphasis on inner speech, is hypothesised to generate and sustain self-awareness, i.e., higher-order consciousness. Converging evidence supporting this hypothesis is reviewed. To account for these findings, a 'HOLISTIC' model of neurobiology of language, inner speech, and consciousness is...

DOI: 10.1016/j.neubiorev.2022.104772 Full text Default mode network Consciousness Core-periphery Efference copy +7

Psychedelic resting-state neuroimaging: A review and perspective on balancing replication and novel analyses.

Neuroscience & Biobehavioral Reviews July 1, 2022 Drummond E-Wen Mcculloch, Gitte Moos Knudsen, Frederick Streeter Barrett et al. 14 citations

Clinical research into serotonergic psychedelics is expanding rapidly, showing promising efficacy across myriad disorders. Resting-state functional magnetic resonance imaging (rs-fMRI) is a commonly used strategy to identify psychedelic-induced changes in neural pathways in clinical and healthy populations. Here we, a large group of psychedelic imaging researchers, review the 42 research...

DOI: 10.1016/j.neubiorev.2022.104689 Full text DMT LSD Psilocin Psilocybin +10

Don’t be afraid, try to meditate- potential effects on neural activity and connectivity of psilocybin-assisted mindfulness-based intervention for social anxiety disorder: A systematic review

Neuroscience & Biobehavioral Reviews June 6, 2022 Corinna L. Felsch, Kim P. C. Kuypers 23 citations

BACKGROUND: Current first-line treatment for social anxiety disorder (SAD), one of the most prevalent anxiety disorders, is limited in its efficacy. Hence, novel treatment approaches are urgently needed. The current review suggests a combination of meditation-based interventions and the administration of a psychedelic as a future alternative treatment approach. While both separate treatments...

DOI: 10.1016/j.neubiorev.2022.104724 Psilocybin Mindfulness Meditation Psychological intervention +6

(R)-ketamine as prophylactic and therapeutic drug for neurological disorders: beyond depression.

Neuroscience & Biobehavioral Reviews June 1, 2022 Xingming Wang, Jianjun Yang, Kenji Hashimoto

Neurological disorders are the leading cause of disability and the second leading cause of death worldwide. The increasing social and economic burdens of neurological disorders are driven by global population growth and aging. Depression is a common psychiatric symptom in numerous neurological disorders. It is also a risk factor for Alzheimer's disease (AD) and other dementias, Parkinson's...

DOI: 10.1016/j.neubiorev.2022.104762 Full text

Dreaming during the COVID-19 pandemic: A narrative review.

Neuroscience & Biobehavioral Reviews May 25, 2022 Maurizio Gorgoni, Serena Scarpelli, Valentina Alfonsi et al.

According to several influential models, dreams can be affected by state- and trait-like factors, sleep features, and diurnal experiences. The COVID-19 pandemic globally affected daily habits, emotional experiences, and sleep. Previous studies suggested an influence of collective traumatic events on dreaming. Starting from these premises, several studies assessed the effect of the pandemic on...

DOI: 10.1016/j.neubiorev.2022.104710 Full text Nightmare Humans Emotions Dreams +4

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