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Nicholas K. Canby

10 papers in the library · 206 citations · publishing 2021-2026

Papers

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Meditation-related psychological adverse effects, challenging, unpleasant, and negative experiences: Toward the safe dissemination and practice of advanced meditation

PsyArXiv March 8, 2026 Oliver Andersson Hugemark, Vanessa Naughton, Karen Vasquez-Avila et al. preprint

Meditation research is increasingly moving beyond the study of health-related benefits toward the investigation of non-ordinary states of consciousness and ways of being that may arise through advanced meditative practice. Alongside potential benefits, however, intensive or advanced meditation has been associated with a higher incidence of meditation-related psychological adverse effects,...

Dietary changes as a risk factor and remedy for meditation-related challenges.

Frontiers in Nutrition October 23, 2025 Josie R Lee, Nicholas K. Canby, David J Cooper et al.

Objectives: Recent research has documented a range of challenging, distressing, or impairing experiences that can result from Buddhist meditation practices (Lindahl et al.). The present study investigates the impact of dietary changes on the trajectories of Western Buddhist meditators who reported meditation-related challenges. Methods: Interviews were conducted with 68 Western Buddhist...

An international Delphi consensus for reporting of setting in psychedelic clinical trials.

Nature Medicine June 3, 2025 Chloé Pronovost-Morgan, Kyle T. Greenway, Leor Roseman et al. 26 citations

Psychedelic substances exhibit complex interactions with the 'set and setting' of use, that is, the mental state of the user and the environment in which a psychedelic experience takes place. Despite these contextual variables' known importance, psychedelic research has lacked methodological rigor in reporting extra-pharmacological factors. This study aimed to generate consensus-based...

DOI: 10.1038/s41591-025-03685-9 (opens in new tab) Full text (opens in new tab) Psychedelic therapy Therapeutic protocols Clinical guidelines Mental health treatment +1

The Teacher Matters: The Role and Impact of Meditation Teachers in the Trajectories of Western Buddhist Meditators Experiencing Meditation-Related Challenges

Contemporary Buddhism April 22, 2025 Nicholas K. Canby, Jared R. Lindahl, David J. Cooper et al. 1 citation

Although meditation is often treated as an individual practice, meditation teachers can play an important role. Drawing on the mixed-methods dataset of the Varieties of Contemplative Experience project, this paper examines the role of meditation teachers and their impacts on Western practitioners who are navigating meditation-related challenges. Quantitative and qualitative results from 68...

Childhood trauma and subclinical PTSD symptoms predict adverse effects and worse outcomes across two mindfulness-based programs for active depression.

PLoS One 2025 Nicholas K. Canby, Elizabeth A Cosby, Roman Palitsky et al. 10 citations

Within mindfulness-based programs (MBPs), mixed results have been found for the role of childhood trauma as a moderator of depression outcomes. Furthermore, childhood trauma and PTSD symptoms have been identified as possible risk factors for the occurrence of meditation-related adverse effects (MRAE). The present research examined multiple forms of childhood trauma and PTSD symptoms as...

Leveraging meditation research for the study of psychedelic-related adverse effects.

International Review of Psychiatry December 1, 2024 Roman Palitsky, Nicholas K. Canby, Nicholas T. van Dam et al. 6 citations

Psychedelics have shown early evidence for a range of benefits and low harm profiles in extant research. However, adverse effects (AEs) research in psychedelics has been limited, leading to underspecified AE profiles, inconsistent measurement, and potential undercounting of AEs. The development of safe, effective psychedelic therapies and treatments for AEs when they occur requires a thorough...

Clarifying and measuring the characteristics of experiences that involve a loss of self or a dissolution of its boundaries.

Consciousness and Cognition March 1, 2024 Nicholas K. Canby, Jared R. Lindahl, Willoughby B. Britton et al. 11 citations

Mystical experience, non-dual awareness, selflessness, self-transcendent experience, and ego-dissolution have become increasingly prominent constructs in meditation and psychedelic research. However, these constructs and their measures tend to be highly overlapping, imprecise, and poorly integrated with similar pathological experiences. The present study seeks to clarify the common factors...

From Self-Esteem to Selflessness: An Evidence (Gap) Map of Self-Related Processes as Mechanisms of Mindfulness-Based Interventions

Frontiers in Psychology November 22, 2021 Willoughby B. Britton, Gaelle Desbordes, Rebecca L. Acabchuk et al. 77 citations

Self-related processes (SRPs) have been theorized as key mechanisms of mindfulness-based interventions (MBIs), but the evidence supporting these theories is currently unclear. This evidence map introduces a comprehensive framework for different types of SRPs, and how they are theorized to function as mechanisms of MBIs (target identification). The evidence map then assesses SRP target...

Defining and measuring meditation-related adverse effects in mindfulness-based programs

Clinical Psychological Science May 18, 2021 Willoughby B. Britton, Jared R. Lindahl, David J. C. Cooper et al.

Research on the adverse effects of mindfulness-based programs (MBPs) has been sparse and hindered by methodological imprecision. The 44-item Meditation Experiences Interview (MedEx-I) was used by an independent assessor to measure meditation-related side effects (MRSEs) following three variants of an 8-week program of mindfulness-based cognitive therapy (n = 96). Each item was queried for...

The Contribution of Common and Specific Therapeutic Factors to Mindfulness-Based Intervention Outcomes

Frontiers in Psychology January 14, 2021 Nicholas K. Canby, Kristina Eichel, Jared R. Lindahl et al. 75 citations

While Mindfulness-Based Interventions (MBIs) have been shown to be effective for a range of patient populations and outcomes, a question remains as to the role of common therapeutic factors, as opposed to the specific effects of mindfulness practice, in contributing to patient improvements. This project used a mixed-method design to investigate the contribution of specific (mindfulness...