Frontiers in Psychology
November 22, 2021
Willoughby B. Britton, Gaelle Desbordes, Rebecca L. Acabchuk et al.
77 citations
Self-related processes (SRPs) such as rumination, self-compassion, self-efficacy, and self-esteem are theorized to be key mechanisms of mindfulness-based interventions (MBIs). This evidence map introduces a framework for categorizing SRPs and assesses how well mindfulness training engages these targets and whether engagement relates to improved outcomes. Rumination shows the strongest evidence as a mechanism for depression, with support for other health outcomes as well. Self-compassion consistently engages with mindfulness training but inconsistently links to better outcomes. Decentering and interoception are emerging potential mechanisms, though their construct validity remains under development. Few SRPs have been measured in MBIs, and more research with well-validated measures is needed.
Nature Medicine
June 3, 2025
Chloé Pronovost-Morgan, Kyle T. Greenway, Leor Roseman et al.
26 citations
A Delphi consensus study with 89 experts from 17 countries identified 30 extra-pharmacological variables that are important or very important for reporting the setting in psychedelic clinical trials. These variables, forming the ReSPCT guidelines, cover physical environment, dosing session procedure, therapeutic framework and protocol, and subjective experiences. The findings reveal significant ambiguities in current conceptualizations of set and setting. The guidelines provide a new standard for designing and documenting contextual factors in psychedelic research.
Consciousness and Cognition
March 1, 2024
Nicholas K. Canby, Jared R. Lindahl, Willoughby B. Britton et al.
11 citations
Experiences like mystical states, non-dual awareness, selflessness, and ego dissolution are increasingly studied in meditation and psychedelic research, but their definitions and measures often overlap and lack precision, especially regarding pathological experiences. In a survey of 386 people who reported an experience involving a loss of self or self-boundaries, researchers used statistical and qualitative methods to identify 16 distinct characteristics of such experiences. These included different types of changes in sense of self, accompanying phenomena, and cognitive or emotional responses. The results provide a more specific model for measuring and describing these experiences across contexts like meditation, psychedelics, and psychopathology.
PLoS One
January 1, 2025
Nicholas K. Canby, Elizabeth A Cosby, Roman Palitsky et al.
10 citations
Childhood trauma and PTSD symptoms are linked to worse depression outcomes and more meditation-related adverse effects in mindfulness-based programs. Across two clinical trials, total childhood trauma and childhood sexual abuse consistently predicted poorer depression outcomes. Childhood sexual abuse also predicted dropout in one study. Multiple forms of trauma and PTSD symptoms predicted meditation-related side effects, while total trauma, emotional abuse, and subclinical PTSD predicted lasting adverse effects. These findings suggest that trauma-sensitive modifications, safety monitoring, screening, and provider education are needed when implementing mindfulness programs for depression.
International review of psychiatry (Abingdon, England)
December 1, 2024
Roman Palitsky, Nicholas K. Canby, Nicholas T. van Dam et al.
6 citations
Research on adverse effects (AEs) of psychedelics has been limited, leading to underspecified profiles and potential undercounting. This article argues that meditation-related AE research, which shares phenomenological and contextual features with psychedelic AEs, offers valuable insights. An integrative review of both fields is presented, recommending that meditation AEs serve as a comparator condition. The authors propose adopting detailed, comprehensive, user-informed, impact-based, standardized, unbiased, and representative measures of AEs, along with examining factors that influence their impacts and trajectories, to advance psychedelic AE research.
Contemporary Buddhism
April 22, 2025
Nicholas K. Canby, Jared R. Lindahl, David J. Cooper et al.
1 citation
Meditation teachers can have both beneficial and detrimental impacts on practitioners facing meditation-related challenges. A mixed-methods study of 68 meditation practitioners and 33 experts from various Buddhist lineages found that beneficial relationships involved access to well-qualified teachers, appropriate guidance, and teachers with psychology or mental health training. Unhelpful factors included teacher unavailability, limited student tracking or disclosure, invalidating or victim-blaming responses, lack of perceived expertise, and mismatched interpersonal or cultural dynamics. The psychologization of Buddhist meditation in the West shapes student-teacher relationships and expectations, especially during challenges.
Clinical psychological science : a journal of the Association for Psychological Science
May 18, 2021
Willoughby B. Britton, Jared R. Lindahl, David J. C. Cooper et al.
In a sample of 96 participants in an 8-week mindfulness-based cognitive therapy program, 83% reported at least one meditation-related side effect when assessed with the Meditation Experiences Interview. Negative-valence effects or negative impacts on functioning occurred in 58% and 37% of participants, respectively. Lasting bad effects, experienced by 6% to 14% of the sample, were linked to signs of dysregulated arousal such as hyperarousal and dissociation. The findings suggest that meditation practice in mindfulness-based programs is associated with transient distress and negative impacts at rates similar to those seen with other psychological treatments.