bioRxiv (Cold Spring Harbor Laboratory)
June 16, 2026
Paulina Clara Dagnino, Irene Acero-Pousa, Gorka Zamora-López et al.
1 citation
Abstract In recent decades, the psychedelic psilocybin has been studied as a potential treatment for major depressive disorder (MDD), offering an alternative to traditional antidepressants. However, the brain changes underlying the clinical effects of different interventions remain unclear. Here, we investigated the effects of psilocybin and a conventional antidepressant, escitalopram, from the...
Entropy (Basel, Switzerland)
April 24, 2025
Prakash Chandra Kavi, Gorka Zamora-López, Daniel Ari Friedman et al.
2 citations
The Thoughtseeds Framework introduces a novel computational approach to modeling thought dynamics in meditative states, conceptualizing thoughtseeds as dynamic attentional agents that integrate information. This hierarchical model, structured as nested Markov blankets, comprises three interconnected levels: (i) knowledge domains as information repositories, (ii) the Thoughtseed Network where...
arXiv Preprint Archive
August 28, 2024
Prakash Chandra Kavi, Gorka Zamora-López, Daniel Ari Friedman
The emergence of cognition requires a framework that bridges evolutionary principles with neurocomputational mechanisms. This paper introduces the novel "thoughtseed" framework, proposing that cognition arises from the dynamic interaction of self-organizing units of embodied knowledge called "thoughtseeds" within the Global Workspace of consciousness. Leveraging foundational concepts from...
Neuroimage
November 1, 2020
Gerald J. Hahn, Gorka Zamora-López, Lynn Uhrig et al.
55 citations
During the sleep-wake cycle, the brain undergoes profound dynamical changes, which manifest subjectively as transitions between conscious experience and unconsciousness. Yet, neurophysiological signatures that can objectively distinguish different consciousness states based are scarce. Here, we show that differences in the level of brain-wide signals can reliably distinguish different stages of...
Prakash Chandra Kavi, Gorka Zamora-López, Daniel Ari Friedman
preprint
The emergence of cognition requires a framework that bridges evolutionary principles with neuro-computational mechanisms. This paper introduces the novel “thoughtseed” framework, proposing that cognition arises from dynamic interactions of self-organizing units of embodied knowledge called “thoughtseeds” within the Global Workspace of consciousness. By leveraging evolutionary theory, neuronal...