Journal of Psychopharmacology
July 16, 2026
Robert F. Dougherty, Nadav Liam Modlin, Niall M. Mcgowan et al.
Background: When administered alongside monitoring and support, psilocybin has shown promise in the treatment of multiple psychiatric conditions. However, the contribution and nature of participant support in the context of psychedelic trials are much debated. Aims: We sought to further illustrate the structure and format of the monitoring and support used in Compass Pathfinder Ltd (Compass)...
Psychopharmacology
August 22, 2023
Robert F. Dougherty, Patrick Clarke, Merve Atli et al.
21 citations
Abstract Rationale Therapeutic administration of psychedelics has shown significant potential in historical accounts and recent clinical trials in the treatment of depression and other mood disorders. A recent randomized double-blind phase-IIb study demonstrated the safety and efficacy of COMP360, COMPASS Pathways’ proprietary synthetic formulation of psilocybin, in participants with...
Proceedings of the National Academy of Sciences of the United States of America
February 15, 2011
Mohammad Dastjerdi, Brett L Foster, Sharmin Nasrullah et al.
The electrophysiological basis for higher brain activity during rest and internally directed cognition within the human default mode network (DMN) remains largely unknown. Here we use intracranial recordings in the human posteromedial cortex (PMC), a core node within the DMN, during conditions of cued rest, autobiographical judgments, and arithmetic processing. We found a heterogeneous profile...
Cerebral Cortex
April 9, 2008
Michael D. Greicius, Kaustubh Supekar, V. Menon et al.
2,227 citations
Resting-state functional connectivity magnetic resonance imaging (fcMRI) studies constitute a growing proportion of functional brain imaging publications. This approach detects temporal correlations in spontaneous blood oxygen level-dependent (BOLD) signal oscillations while subjects rest quietly in the scanner. Although distinct resting-state networks related to vision, language, executive...
Juan Sebastián Gómez-Cañón, Carly Leininger, Danielle Mayall et al.
preprint
Abstract Music plays a central role in psilocybin therapy (PT), where playlists are designed to be supportive and stimulating over a 4–6-hour psychedelic experience. The primary design principle underlying PT music programming is that music should be affectively aligned with the onset–peak–return model of pharmacodynamic action. However, in the absence of clear acoustic criteria, this framework...