Neuron
May 10, 2023
Vinod Menon
832 citations
The discovery of the default mode network (DMN) has revolutionized our understanding of the workings of the human brain. Here, I review developments that led to the discovery of the DMN, offer a personal reflection, and consider how our ideas of DMN function have evolved over the past two decades. I summarize literature examining the role of the DMN in self-reference, social cognition, episodic...
The Behavioral and brain sciences
March 23, 2022
Sarah L Eagleman, David M Eagleman, Vinod Menon et al.
Merker, Williford, and Rudrauf make several arguments against the integrated information theory of consciousness; whereas some have merit, their conclusion that the theory should be discarded is premature. Coming years promise advances in the empirical study of consciousness, and only after theories are independently tested with shared data can they be ruled in or out. We propose future...
Proceedings of the National Academy of Sciences of the United States of America
February 15, 2011
Mohammad Dastjerdi, Brett L Foster, Sharmin Nasrullah et al.
The electrophysiological basis for higher brain activity during rest and internally directed cognition within the human default mode network (DMN) remains largely unknown. Here we use intracranial recordings in the human posteromedial cortex (PMC), a core node within the DMN, during conditions of cued rest, autobiographical judgments, and arithmetic processing. We found a heterogeneous profile...
Neuroimage
April 11, 2010
Kaustubh Supekar, Lucina Q. Uddin, Katherine E. Prater et al.
548 citations
Functional and structural maturation of networks comprised of discrete regions is an important aspect of brain development. The default-mode network (DMN) is a prominent network which includes the posterior cingulate cortex (PCC), medial prefrontal cortex (mPFC), medial temporal lobes (MTL), and angular gyrus (AG). Despite increasing interest in DMN function, little is known about its...
Trang-Anh E. Nghiem, Vinod Menon
preprint
Abstract The default mode network (DMN) plays a fundamental role in internally focused cognition, and its disruption is implicated in numerous brain disorders. While neuroimaging has revealed DMN suppression by salient stimuli, the cellular mechanisms orchestrating this process remain unknown. Using whole-brain computational modeling informed by neuronal biophysics and retrograde tracer-derived...
Vinod Menon, Domenic Cerri, Byeongwook Lee et al.
preprint
Abstract The salience network (SN) and default mode network (DMN) play a crucial role in cognitive function. The SN, anchored in the anterior insular cortex (AI), has been hypothesized to modulate DMN activity during stimulus-driven cognition. However, the causal neural mechanisms underlying changes in DMN activity and its functional connectivity with the SN are poorly understood. Here we...