To quantify the effects of nitrous oxide (N(2)O) gas on electroencephalogram (EEG) topography in healthy male participants. Healthy male participants were administered 20% (n=8) or 40% (n=8) N(2)O while having high-density (modified 10-20) noise minimized EEG recordings. Nitrous oxide was found to produce clear reductions in resting total power, particularly at frontal-vertex sites. These...
Parietal networks are hypothesised to play a central role in the cortical information synthesis that supports conscious experience and behavior. Significant reductions in parietal level functional connectivity have been shown to occur during general anesthesia with propofol and a range of other GABAergic general anesthetic agents. Using two analysis approaches (1) a graph theoretic analysis...
The electrophysiological basis for higher brain activity during rest and internally directed cognition within the human default mode network (DMN) remains largely unknown. Here we use intracranial recordings in the human posteromedial cortex (PMC), a core node within the DMN, during conditions of cued rest, autobiographical judgments, and arithmetic processing. We found a heterogeneous profile...