In Vitro Ketamine Attenuates Immune Sensitization in Major Depressive Disorder in a Concentration-Dependent Manner

Study at a glance

AI-extracted from the abstract

Characteristics	In vitro laboratory study
Population	Blood samples or immune cells from individuals with major depressive disorder
Intervention	Ketamine
Topics	Depression Esketamine Ketamine
Key points	Ketamine attenuated immune sensitization in cells from people with major depressive disorder, with the effect increasing as ketamine concentration rose. The authors suggest this concentration-dependent immune modulation may contribute to ketamine's antidepressant effects, though the in vitro design cannot show clinical benefit.