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Jie Sun

4 papers in the library · 2 citations · publishing 2023-2026

Papers

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Nitrous oxide controls the DCN to VTA dopamine circuit by enhancing AMPA receptor functions during rewarding behavior.

Molecular Psychiatry May 13, 2026 Fukang Zhang, Shuyuan Fan, Shiqi Li et al.

Nitrous oxide (N2O) is a frequently used recreational drug with significant addictive potential. The ventral tegmental area (VTA) is a key brain region associated with the rewarding effects of drugs of abuse. However, how N2O influences VTA functions to mediate reward-related behavior remains poorly understood. We reported that exposure to 60% N2O, but not 30%, effectively induced conditioned...

Psychoactive substances: novel molecular insights and therapeutic potential for Alzheimer's disease.

Translational neurodegeneration July 25, 2025 Chonglei Fu, Xuehui Li, Xiaoxing Liu et al. 2 citations

Alzheimer's disease (AD) is a major neurodegenerative disorder that causes severe cognitive decline and poses a significant burden on global health systems. Despite extensive research, effective treatments to stop neurodegeneration or promote neuronal regeneration in AD remain elusive. Psychoactive substances as modulators of neurophysiological functions, have received increased attention in...

DOI: 10.1186/s40035-025-00498-1 (opens in new tab) Full text (opens in new tab) Alzheimer's disease Challenges Molecular insights Psychoactive substances +6

Self-Transcendence: A Cross-Cultural Study With Democracy in the COVID-19 Pandemic

Cross-Cultural Research August 2, 2023 Jennifer Lau, Yi-Hui Christine Huang, Qinxian Cai et al.

The COVID-19 pandemic and the steps governments took to combat it tormented societies across the globe. Accordingly, existential positive psychologists have emphasized the importance of self-transcendence in mitigating the distress and agony caused by prolonged and rigorous health measures. In this cross-cultural study, the correlation between self-transcendence, people’s confidence in...

Esketamine pretreatment during cesarean section reduced the incidence of PPD: A randomized controlled trail

Shixia Xu, Jiaojiao Yang, Jing Li et al. preprint

Abstract Background Postpartum depression (PPD) is a common mental disease in postpartum women, which has received more and more attention in society. Ketamine has been confirmed for its rapid antidepressant effect in women with PPD. We speculate that esketamine, an enantiomer of ketamine, pretreatment during cesarean can also reduce the incidence of PPD. Methods All the parturients enrolled in...