PsyArXiv
May 14, 2026
Jacob Cohen, Peter Parbo, Per Trads Ørskov et al.
preprint
Low doses of psilocybin as adjunct pharmacological treatment to virtual reality exposure therapy for social anxiety disorder: A study protocol for a double-blind randomized controlled trial.
Scientific Reports
March 25, 2026
Johannes Björkstrand, Emil Olsson, Oisín Hugh Clancy et al.
Fear-based disorders affect millions worldwide, yet current treatments show limited effectiveness for many patients. While mindfulness is increasingly used clinically for anxiety and trauma disorders, the neural mechanisms underlying its effects on fear processing remain unclear. We conducted a randomized controlled trial using 7T fMRI to test whether mindfulness training enhances fear...
JMIR mHealth and uHealth
October 23, 2025
Walter Staiano, Christine E Callahan, Michelle Davis et al.
Anxiety and depressive disorders affect hundreds of millions globally, with substantial barriers limiting access to evidence-based treatments like cognitive behavioral therapy. Digital mental health interventions offer potential solutions to improve access to support. However, evidence of efficacy through randomized controlled trials is essential for clinical adoption. This study evaluated the...
Social Cognitive and Affective Neuroscience
September 4, 2014
Ulrich Kirk, Kirk Warren Brown, Jonathan Downar
66 citations
Reward seeking is ubiquitous and adaptive in humans. But excessive reward seeking behavior, such as chasing monetary rewards, may lead to diminished subjective well-being. This study examined whether individuals trained in mindfulness meditation show neural evidence of lower susceptibility to monetary rewards. Seventy-eight participants (34 meditators, 44 matched controls) completed the...
Frontiers in Neuroscience
2011
Ulrich Kirk, Jonathan Downar, P. Read Montague
167 citations
Human decision-making is often conceptualized as a competition between cognitive and emotional processes in the brain. Deviations from rational processes are believed to derive from inclusion of emotional factors in decision-making. Here, we investigate whether experienced Buddhist meditators are better equipped to regulate emotional processes compared with controls during economic...