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Jacob Cohen

4 papers in the library · 2 citations · publishing 2024-2026

Papers

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Low doses of psilocybin as adjunct pharmacological treatment to virtual reality exposure therapy for social anxiety disorder: A study protocol for a double-blind randomized controlled trial.

PsyArXiv May 14, 2026 Jacob Cohen, Peter Parbo, Per Trads Ørskov et al. preprint

Background: Social anxiety disorder is a chronic and disabling condition with limited response to standard therapies. Low-dose psilocybin may enhance the effectiveness of exposure-based treatments by modulating neural circuits associated with fear and avoidance. Virtual reality exposure therapy offers a controlled and individualized platform for intervention. Objective: This phase 2b,...

DOI: 10.31234/osf.io/3b9fx_v1 (opens in new tab)

Case Report: Repeated low doses of psilocybin reduce perceived symptom severity but fail to restore cognitive flexibility in a case of severe obsessive-compulsive disorder: an observational case study of identical twins.

Frontiers in Psychiatry 2026 Sivert Drange, Jacob Cohen, Sys Stybe Johansen et al. 1 citation

Obsessive-Compulsive Disorder (OCD) can present significant challenges to individuals mental health, characterized by intrusive thoughts and repetitive maladaptive behaviors. Recent research into alternative treatments has highlighted psychedelics, notably psilocybin, for their potential therapeutic benefits in various psychiatric disorders, including OCD. This case study evaluated the impact...

DOI: 10.3389/fpsyt.2026.1819962 (opens in new tab) Full text (opens in new tab) Psilocybin Case report Case study Cognitive flexibility +3

Novel Neurobiological Approaches to Anxiety-Related Disorders: Clinical and Neuroimaging Investigations of Psilocybin and Ketamine-Based Interventions

University of Southern Denmark Research Portal (University of Southern Denmark) September 9, 2025 Jacob Cohen

Angst og traumarelaterede lidelser,herunder generaliseret angstlidelse (GAD), obsessiv-kompulsiv lidelse (OCD), posttraumatisk stresslidelse (PTSD) og social angstlidelse (SAD), er meget udbredte og reagerer ofte dårligt på konventionel farmakologisk behandling og psykoterapi. Nyere kliniske forsøg har vist, at psykedeliske stoffer og ketamin kan udøve hurtige og vedvarende effekter gennem...

DOI: 10.21996/1d48c7a5-f86f-44cc-a637-d7fae8f75e1a (opens in new tab) Psilocybin Psychotherapist Psychological intervention Neuroimaging

Repeated low doses of psilocybin reduces perceived symptom severity of obsessive-compulsive disorder, but fails to restore cognitive flexibility: A case study of identical twins

December 30, 2024 Sivert Drange, Jacob Cohen, Sys Stybe Johansen et al. 1 citation preprint

Background: Obsessive-Compulsive Disorder (OCD) presents significant challenges to individuals mental health, characterized by intrusive thoughts and repetitive maladaptive behaviours. Recent exploration into alternative treatments has spotlighted psychedelics, notably psilocybin, for their potential therapeutic benefits in different psychiatric disorders, including OCD. This case study delves...

DOI: 10.31219/osf.io/2bxe8 (opens in new tab) Psilocybin Obsessive compulsive Cognitive flexibility Flexibility engineering +3