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Adrián Ponce-Alvarez

5 papers in the library · 69 citations · publishing 2021-2026

Papers

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Long-term effects of psilocybin on dynamic and effectivity connectivity of fronto-striatal-thalamic circuits

bioRxiv (Cold Spring Harbor Laboratory) November 7, 2024 Lorenzo Pasquini, Jakub Vohryzek, Anira Escrichs et al. 4 citations preprint

Abstract Psilocybin has been shown to induce fast and sustained improvements in mental well-being across various populations, yet its long-term mechanisms of action are not fully understood. Initial evidence suggests that longitudinal functional and structural brain changes implicate fronto-striatal-thalamic (FST) circuitry, a broad system involved in goal-directed behavior and motivational...

LSD-induced increase of Ising temperature and algorithmic complexity of brain dynamics.

PLoS Computational Biology February 1, 2023 Giulio Ruffini, Giada Damiani, Diego Lozano-Soldevilla et al. 28 citations

A topic of growing interest in computational neuroscience is the discovery of fundamental principles underlying global dynamics and the self-organization of the brain. In particular, the notion that the brain operates near criticality has gained considerable support, and recent work has shown that the dynamics of different brain states may be modeled by pairwise maximum entropy Ising models at...

Functional network antagonism and consciousness.

Network neuroscience (Cambridge, Mass.) 2022 Athena Demertzi, Aaron Kucyi, Adrián Ponce-Alvarez et al.

Spontaneous brain activity changes across states of consciousness. A particular consciousness-mediated configuration is the anticorrelations between the default mode network and other brain regions. What this antagonistic organization implies about consciousness to date remains inconclusive. In this Perspective Article, we propose that anticorrelations are the physiological expression of the...

Increased sensitivity to strong perturbations in a whole-brain model of LSD.

Neuroimage January 29, 2021 Beatrice M. Jobst, Selen Atasoy, Adrián Ponce-Alvarez et al. 37 citations

Lysergic acid diethylamide (LSD) is a potent psychedelic drug, which has seen a revival in clinical and pharmacological research within recent years. Human neuroimaging studies have shown fundamental changes in brain-wide functional connectivity and an expansion of dynamical brain states, thus raising the question about a mechanistic explanation of the dynamics underlying these alterations....