Modeled Long-Term Effects of Psilocybin on Dynamic Activity and Effective Connectivity of Fronto-Striatal-Thalamic Circuits.
Lorenzo Pasquini, Jakub Vohryzek, Anira Escrichs, Yonatan Sanz Perl, Adrián Ponce-Alvarez, Sebastián Idesis, Manesh Girn, Leor Roseman, Jennifer Mitchell, Adam Gazzaley, Morten L. Kringelbach, David Nutt, Taylor Lyons, Robin Carhart-Harris, Gustavo Deco
Hum Brain Mapp July 1, 2026 DOI: 10.1002/hbm.70596 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Computational modeling study Peer reviewed |
|---|---|
| Intervention | Psilocybin |
| Topics | Psilocybin |
| Key points | Modeled psilocybin exposure produces lasting alterations in fronto-striatal-thalamic circuit dynamics and effective connectivity, suggesting a neural mechanism for sustained therapeutic effects. |
Abstract
Modeled Long-Term Effects of Psilocybin on Dynamic Activity and Effective Connectivity of Fronto-Striatal-Thalamic Circuits.