Drug Testing and Analysis
April 28, 2011
Joanne C Lin, Reem Kais Jan, Robert R. Kydd et al.
70 citations
The use of piperazine derivatives, colloquially named 'party pills', has been escalating in New Zealand and worldwide since their introduction in the 1990s. Benzylpiperazine (BZP) is often used alone, or can be combined with trifluoromethylphenylpiperazine (TFMPP). Taken together as an oral dose, they have been reported to produce effects similar to 3, 4-methylenedioxymethamphetamine (MDMA)....
British Journal of Pharmacology
April 21, 2011
Daniel José Barbosa, João Paulo Capela, Jorge M.A. Oliveira et al.
60 citations
BACKGROUND AND PURPOSE: 3,4-Methylenedioxymethamphetamine (MDMA or 'Ecstasy') is a worldwide major drug of abuse known to elicit neurotoxic effects. The mechanisms underlying the neurotoxic effects of MDMA are not clear at present, but the metabolism of dopamine and 5-HT by monoamine oxidase (MAO), as well as the hepatic biotransformation of MDMA into pro-oxidant reactive metabolites is thought...
Dusunen Adam: The Journal of Psychiatry and Neurological Sciences
April 21, 2011
Gökhan Umut, İlker Küçükparlak, Güliz Özgen et al.
2 citations
A mood disorder episode with an onset under chronic cannabis consumption and accompanied with psychotic features immediately after N,N-Dimethyltryptamine (DMT) use: case report N,N-dimethyltryptamine (DMT) is a serotonin agonist hallucinogen, similar to lysergic acid diethylamide (LSD).Synthetic production of DMT as well as extraction from several plants of South American flora is possible.DMT...
The FASEB Journal
April 1, 2011
Kevin S. Murnane, Leonard L. Howell
3,4-methylenedioxymethamphetamine (MDMA) is a substituted amphetamine derivative that is widely abused as the street drug “ecstasy”. Despite its high abuse liability, the neuropharmacology of MDMA remains poorly understood. In the present study, functional magnetic resonance imaging (fMRI) was used in fully conscious rhesus monkeys to characterize the neuroactivational effects of MDMA and its...
The Open Addiction Journal
March 29, 2011
Abdallah Salem
1 citation
Project Background The main MDMA-induced adverse effect is disruption of normal thermoregulation leading to life threatening hyperthermia which is exacerbated by high ambient temperature and linked to chronic neurotoxicity. Although the focus of the majority of research on MDMAinduced loss of thermoregulation has been on brain serotonergic and dopaminergic systems, results obtained from our...
The Open Addiction Journal
March 29, 2011
Jillian H. Broadbear
1 citation
are examples of interoceptive cues which enable experienced users to distinguish the effects of MDMA from those of other drugs. Serotonin neurotransmission positively modulates the release of oxytocin into plasma [2]. To test the hypothesis that oxytocin receptor activation contributes to the interoceptive cues of MDMA in male and female rats, two peptidic oxytocin receptor ligands, the agonist...
The Open Addiction Journal
March 29, 2011
David N. Harper
5 citations
disruption to working memory function [1, 2]. This possibility was examined using a version of the 8-arm radial maze task with rats that is designed to separate working memory function from reference memory function [3]. In Experiment 1 the effects of MDMA were compared to the classic amnetic drug scopolamine (which has been shown to produce working memory deficits in the current radial arm...
Neuropsychopharmacology
March 2011
Yen F Tai, Rosa Hoshi, Catherine M Brignell et al.
Ecstasy (±3,4-methylenedioxymethamphetamine, MDMA) is a popular recreational drug with known serotonergic neurotoxicity. Its long-term effects on dopaminergic function are less certain. Studying the long-term effects of ecstasy is often confounded by concomitant polydrug use and the short duration of abstinence. We used (18)F-dopa positron emission tomography (PET) to investigate the long-term...
Planta Medica
March 1, 2011
Lj Standish, Dean B. Reardon, Simon Phipps et al.
Ayahuasca is an ancient psychoactive ethnobotanical medicine tea used by indigenous S. American tribes as a religious sacrament. It is made from the vine of B. caapi and the leaves of P. viridis and represents an ancient yet 'novel' short and long-term serotonin agonist. Here we present preclinical pharmacognosy data as an early step towards phase I and II clinical trials of ayahuasca in...
Current Neuropharmacology
March 1, 2011
Zbigniew Binienda, Michael A Beaudoin, Brett T Thorn et al.
10 citations
Advances in computer technology have allowed quantification of the electroencephalogram (EEG) and expansion of quantitative EEG (qEEG) analysis in neurophysiology, as well as clinical neurology, with great success. Among the variety of techniques in this field, frequency (spectral) analysis using Fast Fourier Transforms (FFT) provides a sensitive tool for time-course studies of different...