The present study was undertaken to examine effects of self-administered MDMA on novel object exploration (NOR) memory. Self-administration was conducted during daily 2 h tests that continued until a total of 165 mg/kg was self-administered (range = 13-41 days for individual rats). Control rats were placed in the self-administration boxes during daily sessions but did not receive any drug. One...
Both acute and chronic exposure to 3, 4-methylenedioxymethamphetamine (MDMA) is associated with impairments in a range of conditional discrimination tasks that reflect memory function, decision making and self-control [1-3]. However, the mechanism by which MDMA decreases performance in these tasks is not clear. One interpretation of such findings has been that overall stimulus control is...
disruption to working memory function [1, 2]. This possibility was examined using a version of the 8-arm radial maze task with rats that is designed to separate working memory function from reference memory function [3]. In Experiment 1 the effects of MDMA were compared to the classic amnetic drug scopolamine (which has been shown to produce working memory deficits in the current radial arm...
This study used the Drug Discrimination paradigm to assess the relative subjective experience of acutely administered 3,4-Methylenedioxymethamphetamine (MDMA) and d-amphetamine (AMPH). In this paradigm rats are required to respond on one lever if they have been given a specific drug (AMPH for one group of rats or MDMA for another group) vs an alternate lever if they have been administered...
Recent evidence suggests that the disruptive effects of acute exposure to (+/-)3,4-methylene dioxymethamphetamine (MDMA) on memory performance may be the result of increased confusion between previous-trial and current-trial events. The current study tested this hypothesis by examining the effects of MDMA on performance of rats in a delayed matching-to-sample procedure when the length of the...