Neuropsychopharmacology
March 2011
Yen F Tai, Rosa Hoshi, Catherine M Brignell et al.
Ecstasy (±3,4-methylenedioxymethamphetamine, MDMA) is a popular recreational drug with known serotonergic neurotoxicity. Its long-term effects on dopaminergic function are less certain. Studying the long-term effects of ecstasy is often confounded by concomitant polydrug use and the short duration of abstinence. We used (18)F-dopa positron emission tomography (PET) to investigate the long-term...
The British Journal of Psychiatry
March 31, 2009
Sudhakar Selvaraj, Rosa Hoshi, Zubin Bhagwagar et al.
59 citations
Background Animal experimental studies have prompted concerns that widespread use of 3,4-methylenedioxymethamphetamine (MDMA; ‘ecstasy’) by young people may pose a major public health problem in terms of persistent serotonin neurotoxicity. Aims To determine the status of brain serotonin neurons in a group of abstinent MDMA users. Method We assessed the integrity of brain serotonin neurons by...
Psychopharmacology
October 2007
Rosa Hoshi, Kate Mullins, Catherine Boundy et al.
Despite years of research and much controversy surrounding the effects of ecstasy use, findings are equivocal. Attempting to reduce methodological problems, such as concurrent use of other recreational drugs, could lead to a clearer picture of the effects of ecstasy use on cognitive function. The aim of this study is to investigate the effects of both prolonged abstention from ecstasy use and...
Experimental and Clinical Psychopharmacology
August 2007
Rosa Hoshi, Lisa Cohen, Lucy Lemanski et al.
+/-3, 4-methylenedioxymethamphetamine (MDMA or ecstasy) remains a widely used recreational drug, which, in animals, can produce long-lasting changes to the brain's serotonergic system. As serotonin has been implicated in human aggression, it is possible that ecstasy users are at risk of increased aggression even after prolonged abstention from the drug. The objective of this study was to...
Journal of Psychopharmacology
March 2006
Rosa Hoshi, Hannah Pratt, Sachin Mehta et al.
The lowering of serotonin for a period following MDMA use could account for the increases in both self-rated and objective measures of aggression previously found in ecstasy users several days after taking the drug. There is some evidence of gender differences in the acute, sub-acute and long-term effects of MDMA use, and given that gender differences have been found in aggression, it is...