Pharmacology, Biochemistry, and Behavior
May 1, 1975
Ronald G. Browne, Beng T. Ho
51 citations
Rats were trained to discriminate intraperitoneally administered mescaline from saline in a two-lever operant chamber for food reinforcement. Reward was contingent upon responses made greater than 15 sec apart (DRL-15) on the appropriate lever paired with either drug or saline administration. Following the establishment of discriminative response control by mescaline, the animals were tested...
Pharmacology, Biochemistry, and Behavior
1975
Mark A. Geyer, J D Warbritton, D B Menkes et al.
34 citations
Rat startle responses to air puffs were monitored in a stabilimeter during the intraventricular infusion of various doses of 5-hydroxytrptamine (5-HT) or the putative hallucinogenic congener of 5-HT, 5-hydroxy-N, N-dimethyltrytamine (5-HDMT) or saline. Qualitativity opposite effects were observed, with 5-HT producing a dose-dependent decrease in responsivity and 5-HDMT increasing the magnitude...
Proceedings of the National Academy of Sciences
March 1, 1974
James A. Nathanson, Paul Greengard
95 citations
An adenylate cyclase (EC 4.6.1.1) that is activated specifically by low concentrations of serotonin has been identified in homogenates of the thoracic ganglia of an insect nervous system. The activation of this enzyme by serotonin was selectively inhibited by extremely low concentrations of D-lysergic acid diethylamide (LSD), 2-bromo-LSD, and cyproheptadine, agents which are known to block...
Science
1969
Robert C. Lin, S. H. Ngai, E. Costa
69 citations
Injections of D-lysergic acid diethylamide decrease the turnover rate of 5-hydroxytryptamine of rat brain, as measured from the conversion of (14)C-tryptophan into (14)C-5-hydroxytryptamine. The 2-bromolysergic acid diethylamide given in doses fivefold greater than those of lysergic acid diethylamide fails to change the rate of (14)C-tryptophan conversion into (14)C-5-hydroxytryptamine. The...
Science
September 22, 1967
Thomas N. Chase, George R. Breese, Irwin J. Kopin
1 citation
Slices of rat brain which had accumulated tritiated serotonin either in vivo or in vitro were superfused and electrically stimulated. There occurred a marked release of the exogenous amine and, to a lesser extent, its deaminated metabolites, which varied with the region of brain tested and was inhibited by lysergic acid diethylamide.
Science
June 1, 1962
D. W. Woolley, N.k. Campbell
13 citations
These psychotomimetic analogs of serotonin act like this hormone in some tests and against it in others.
Journal of Pharmacology and Experimental Therapeutics
November 1, 1961
D. X. Freedman
LSD-25 in doses of 130 to 1300 µg/kg induced a small and significant rise in levels of rat brain serotonin within 10 to 120 minutes following administration. A single dose was as effective as several daily doses. In reserpine treated animals, LSD-25 induced a 2-fold elevation in brain serotonin, and effects were found 96 hours following a single dose of LSD-25. A dose-effect interaction of...
Experimental Biology and Medicine
1956
E. Costa
64 citations
SummaryTranquilizing drugs: Frenquel (0.8 mg/1), chlorpromazine (0.1 mg/1) and reserpine (0.4 mg/1), antagonize serotonin-induced uterine contractions, though they do not affect sensitivity of the uterus of the spayed rat either to ACh or oxytocin. The period of antagonism is longer lasting with reserpine than with chlorpromazine and is shortest with Frenquel. Mescaline (0.1 mg/1) causes a...
Journal of Clinical Psychopharmacology
Nicole Ledwos, Joshua D. Rosenblat, Daniel M. Blumberger et al.
16 citations
There has been resurgence of interest in the therapeutic use of serotonergic ("classic") psychedelics in major depressive disorder (MDD) and end-of-life distress. This commentary offers a critical appraisal of current evidence for antidepressant effects of classic psychedelics from contemporary clinical trials and highlights pitfalls that should be addressed before clinical translation. A...
Anaid Flores, Imelda Lizeth Lazcano-Carrasco, Mayra Lozano-Espinosa et al.
preprint
Abstract Psychedelic compounds have shown promising efficacy in the treatment of psychiatric disorders, yet the electronic features of their recognition by the serotonin 2A receptor (5-HT 2A ) remain poorly characterized. Here, we present a quantum-chemical analysis of local ligand–receptor models derived from the experimental 5-HT 2A structures of six ligands: serotonin, psilocin, lysergic...