Zenodo (CERN European Organization for Nuclear Research)
October 29, 2026
Marcel Pierrelouis, Pablo Iturralde
1 citation
preprint
Psychedelic therapy is usually explained by what happens at the peak of the session. We argue the explanation sits on the wrong side of the experience. Drawing on first-person accounts of ego dissolution and on the reconsolidation literature, we set out a four-phase account in which the therapeutic event is not the dissolution and not the mystical peak, but the reassembly of self-referential...
medRxiv
October 29, 2026
Ceyda Sayalı, Eli Weisman, Frederick Streeter Barrett
preprint
Background. Change in cognitive control is a candidate transdiagnostic mechanism of psychedelic therapy. One account predicts that, once acute effects resolve, psilocybin shifts control toward flexibility while sparing inhibition and working memory. A motivational account (PRISM) predicts that psilocybin increases the willingness to exert control rather than the ability to do so. We tested both...
Frontiers in Psychiatry
October 28, 2026
Maria Åkesson, Pehr Granqvist, Robert Johansson et al.
BackgroundPsychedelic retreats are increasingly used to promote wellbeing outside clinical settings, yet the psychological processes associated with sustained improvements in wellbeing remain poorly understood. From a public mental health perspective, identifying mechanisms that support positive mental health beyond symptom reduction is of growing importance.MethodsThis naturalistic...
Discover Mental Health
October 27, 2026
Safa Rubaye, Aditya Shah, Waleed Aldulaimy et al.
Ketamine is an important intervention for severe depression and trauma-related psychopathology, but the optimal way to provide therapeutic support during treatment remains unclear. Although ketamine-assisted psychotherapy is clinically appealing, maintaining therapist presence throughout every dosing session can be logistically difficult. Virtual reality (VR) may offer a structured, scalable,...
Contemporary Clinical Trials Communications
October 27, 2026
Leslie A. Morland, Bettye E Chargin, Barbara Olasov Rothbaum et al.
Posttraumatic stress disorder (PTSD) remains prevalent and disabling, especially among veterans, with a substantial proportion failing to achieve remission following first-line evidence-based trauma-focused psychotherapies. 3,4-Methylenedioxymethamphetamine (MDMA) is hypothesized to enhance psychotherapy outcomes through effects on fear extinction, cognitive flexibility, and emotional...
Theory & Psychology
October 27, 2026
Brian Nuckols
Contemporary psychology treats the construction, maintenance, and enhancement of a coherent self-concept as the implicit telos of therapeutic intervention, an assumption so thoroughly embedded in clinical training, diagnostic frameworks, and outcome measurement that it functions less as a theoretical commitment than as a perceptual habit. This article argues that compulsive identity maintenance...
Journal of Psychopharmacology
October 27, 2026
José Augusto Silva Reis, Lara Zancaner Ueta, José Carlos Bouso et al.
This systematic review evaluates the relationship between classical psychedelic drugs (D-Lysergic acid N,N-diethylamide, psilocybin, ayahuasca/N-N-dimethyl-tryptamine, and mescaline) and the emergence of psychotic symptoms, aiming to synthesize evidence from contemporary studies (1984-2025) regarding the risk factors, prevalence, and clinical characteristics of psychosis related to psychedelic...
Behavioral Sciences
October 26, 2026
Antonio Inserra, Luca Persico, Arianna Rosati et al.
Public and patient interest in psychedelic-assisted psychotherapy is increasing, but people seeking access to psychedelic trials may be more clinically heterogeneous than the populations these trials can enrol. We conducted a cross-sectional descriptive analysis of previously unreported aggregate telephone-screening data from the coordinating site of PRIDE, an ongoing Italian multicentre phase...
Psychology Archives
October 22, 2026
Lukas Andreas Basedow, Andreas Reis, Irina Falkenberg et al.
Background: Shame is a component that contributes to psychopathology yet few interventions target it directly. Psychedelic-assisted therapy has been investigated as an intervention targeting shame and its associated burden. As part of psychedelic efficacy is mediated by expectation effects the true effect a psychedelic intervention may provide is unknown. Here we examined whether a psychedelic...
PsyArXiv Preprints
October 22, 2026
preprint
Background: Subjective experiences featuring altered self-awareness, temporal perception, or spatial boundaries—termed Non-Ordinary Experiences (NOEs)—occur across clinical neurology, psychiatry, and psychedelic medicine, including in insular ecstatic seizures, meditation, breathwork, hypnosis, and psychedelic therapy. Objective: To synthesize neurobiological and clinical literature on NOEs for...