Abstract The emergence of non-hallucinogenic psychoplastogens signals a profound philosophical and therapeutic chasm in the discourse surrounding psychedelic medicine. Unlike psychedelic-assisted therapy, which emphasizes subjective experience as central to healing, psychoplastogens are framed as purely neuroplasticity-driven treatments, aiming to repair brain circuits without inducing altered...
Sponsor companies and physician investigators engaged in clinical research, including those involved in psychedelic drug development, are to design quality into the clinical studies upfront as outlined in International Council for Harmonization (ICH) E8 R1, General Considerations for Clinical Studies, and ICH E6 R3, Guideline for Good Clinical Practice. Identification of what is critical to...
The resurgence in research with classic psychedelics (e.g. LSD, psilocybin) underscores their potential for improved well-being; however, the interpersonal context and mechanisms of psychedelic impacts remain unknown. In a sample of 798 participants (81 couples), this survey study tested whether use of a psychedelic with a romantic partner (v. not together) was associated with couples' shared...
Adolescent mental health conditions, particularly treatment-resistant depression (TRD), represent a growing public health challenge associated with high morbidity, functional impairment, and elevated suicide risk. Psychedelic-assisted therapies have shown robust antidepressant and transdiagnostic effects in rigorously controlled adult trials. Extending this work to adolescents is scientifically...
Binge Eating Disorder (BED) is the most prevalent eating disorder and is associated with psychiatric comorbidities, health impairments, and decreased quality of life. Emerging evidence suggests that psilocybin-assisted therapy may promote cognitive and emotional flexibility and disrupt maladaptive behavioral patterns, making it a promising candidate for BED treatment. This open-label pilot...
2026Canyon Akromis, Lorraine Li, Kwon Mok Ko et al.
preprint
This project is a secondary analysis of data from Psilocybin in Depression Resistant to Standard Treatments (PsiDeR) study, a phase II, randomised, placebo-controlled clinical trial where participants with treatment resistant depression received either 25 mg of psilocybin or a placebo alongside psychotherapy. This research seeks to determine whether the therapeutic alliance, measured by the...
This project is a scoping review examining the relationship between self-compassion, compassion, and psychedelic experiences or psychedelic-assisted therapies. The purpose of the review is to systematically identify, chart, and synthesize the existing literature on how compassion-related constructs are conceptualized, measured, and discussed in psychedelic research. The review will include...
Practices involving altered states of consciousness (ASCs) are receiving increasing scientific and public attention, particularly in domains such as psychedelic assisted therapy and mindfulness-based interventions (Lee et al., 2021; Nichols et al., 2017). There is also an increasing interest in a broader range of practices involving altered states, including breathwork, ice-bath immersions,...
This project investigates whether high ventilation breathwork (HVB) may support mental health through psychological mechanisms that have been proposed in the psychedelic-assisted therapy literature. HVB can reliably induce altered states of consciousness (ASCs) and has been discussed as a potentially low-threshold, non-pharmacological alternative to psychedelic interventions for conditions such...
This project explores a translational research framework for trauma recovery and post-traumatic stress disorder (PTSD) integrating evidence from psychoplastogenic compounds, autonomic regulation, interoceptive neuroscience, affective somatosensory signaling, psychophysiology, and structured somatic intervention. The work emphasizes rigorous evidence stratification, methodological transparency,...