Seeing and Perceiving
2012
David Luke, Devin B. Terhune, Ross Friday
11 citations
The neurobiology of synaesthesia is receiving growing attention in the search for insights into consciousness, such as the binding problem. One way of decoding the neurocognitive mechanisms underlying this phenomenon is to investigate the induction of synaesthesia via neurochemical agents, as commonly occurs with psychedelic substances. How synaesthesia is affected by drugs can also help inform...
Psychiatric News
December 16, 2011
Joan Arehart-Treichel
Even if ingesting the hallucinogen psilocybin can increase positive feelings of bliss or oneness with the universe, it is questionable whether such feelings represent authentic mystical experience or spiritual growth.
Humana Press eBooks
August 26, 2011
Javed Khan, Thomas J. Kennedy, Donnell R. Christian
2 citations
Natural and synthetic analogs of tryptamine are introduced as a class of hallucinogenic drugs derived from indole. The forensic identification of psilocin, psilocybin, bufotenin, 5-methoxy-N,N-dimethyltryptamine (5MeODMT), 5-methoxy-N,N-diisopropyltryptamine (5MeODIPT, aka foxy methoxy), N,N-diethyltryptamine (DET), and alpha-ethyltryptamine (AET) is discussed. Structural formulas are provided...
Journal of Psychoactive Drugs
July 1, 2011
Anette Kjellgren, Christophe Soussan
52 citations
The psychoactive substance 4-HO-MET (4-hydroxy-N-methyl-N-ethyltryptamine) with psychedelic qualities is one of many legal so-called Internet drugs. The aim of this qualitative study was to establish an understanding of what characterizes its recreational use. Very little is known about the effects of this substance. Twenty-five anonymous Swedish experience reports (from persons aged 18-30...
Journal of Psychoactive Drugs
July 1, 2011
Levente Móró, Katalin Simon, Imre Bárd et al.
138 citations
Psychoactive drug use shows great diversity, but due to a disproportionate focus on problematic drug use, predominant nonproblematic drug use remains an understudied phenomenon. Historic and anecdotal evidence shows that natural sources of "psychedelic" drugs (e.g., mescaline and psilocybin) have been used in religious and spiritual settings for centuries, as well as for psychological...
Journal of Pharmacology and Experimental Therapeutics
April 8, 2011
Michael B. Gatch, Michael J. Forster, Aaron Janowsky et al.
42 citations
The abuse liability profile of three synthetic hallucinogens, N,N-diisopropyltryptamine (DIPT), 5-N,N-diethyl-5-methoxytryptamine (5-MeO-DET), and 5-methoxy-α-methyltryptamine (5-MeO-AMT), was tested in rats trained to discriminate hallucinogenic and psychostimulant compounds, including cocaine, methamphetamine, 3,4-methylenedioxymethylamphetamine (MDMA), lysergic acid diethylamide (LSD),...
Neuropharmacology
January 20, 2011
Adam L. Halberstadt, Mark A. Geyer
Serotonergic hallucinogens produce profound changes in perception, mood, and cognition. These drugs include phenylalkylamines such as mescaline and 2,5-dimethoxy-4-methylamphetamine (DOM), and indoleamines such as (+)-lysergic acid diethylamide (LSD) and psilocybin. Despite their differences in chemical structure, the two classes of hallucinogens produce remarkably similar subjective effects in...
Journal of Psychopharmacology
December 8, 2010
Liselore Koedood, Adam L. Halberstadt, Susan B Powell et al.
212 citations
Psilocin (4-hydroxy- N, N-dimethyltryptamine) is a hallucinogen that acts as an agonist at 5-HT 1A , 5-HT 2A , and 5-HT 2C receptors. Psilocin is the active metabolite of psilocybin, a hallucinogen that is currently being investigated clinically as a potential therapeutic agent. In the present investigation, we used a combination of genetic and pharmacological approaches to identify the...
PLoS One
December 2, 2010
Gantt P. Galloway, Jennifer D. Siegrist, Lynn C. Robertson et al.
22 citations
BACKGROUND: The mechanisms of drug-induced visions are poorly understood. Very few serotonergic hallucinogens have been studied in humans in decades, despite widespread use of these drugs and potential relevance of their mechanisms to hallucinations occurring in psychiatric and neurological disorders. METHODOLOGY/PRINCIPAL FINDINGS: We investigated the mechanisms of hallucinogen-induced visions...
Journal of Substance Use
July 30, 2010
R. L. Carhart-Harris, D. J. Nutt
108 citations
This study used a web-based questionnaire to investigate user perceptions of the benefits and harms of hallucinogenic drug use. Over 600 forms were submitted. Users were asked to comment on the acute and prolonged effects of different drugs and to provide more specific information on how particular drugs have harmed and/or helped them. Subjects reported relatively less harm associated with the...