Current Medicinal Chemistry
April 28, 2026
Long-term memory exhibits a remarkable problem: it is extraordinarily stable over decades, yet it supports rapid, flexible cognition, logic, and conscious awareness. Classical neuroscience has largely attributed memory to synaptic plasticity and networklevel dynamics; however, these mechanisms alone do not adequately explain the molecular durability of memory traces in the face of continuous...
Current Medicinal Chemistry
September 24, 2025
The author had previously proposed that memory could be encoded as patterns of hydrogen-bonded "frozen" conformers of neuronal glycoproteins. These stabilised molecular patterns represent an ideal template for information storage in the human brain because of the large number of asymmetric centres present in sugar molecules with attached hydroxyl groups. Hydrogen bonding of hydroxyl groups...
Current Medicinal Chemistry
June 2, 2025
Jinlong Zhang, Xingxing Dang, Jiang Lin et al.
The incidence of psychiatric disorders, such as post-traumatic stress disorder (PTSD), anxiety, and depression, has been steadily increasing, while current treatment approaches remain limited in efficacy. As a result, there is an urgent need to explore more effective therapeutic interventions. In recent years, MDMA (3,4- methylenedioxymethamphetamine)-assisted therapy (MDMA-AT) has emerged as a...
Current Medicinal Chemistry
December 13, 2019
Genís Ona, José Carlos Bouso
15 citations
In the drug development, the formation of highly selective ligands has been unsuccessful in the treatment of central nervous system disorders. Multi-target ligands, from the polypharmacology paradigm, are being proposed as treatments for these complex disorders, since they offer enhanced efficacy and a strong safety profile. Natural products are the best examples of multi-target compounds, so...
Current Medicinal Chemistry
August 20, 2009
John S. Adams
7 citations
Pyramidal neurons in layer 5 of the cerebral cortex are involved in learning and memory and have complex connections with other neurons through a very large array of dendrites. These dendrites can switch between long term depression and long term potentiation depending on global summation of various inputs. The plasticity of the input into pyramidal neurons makes the neuronal output variable....
Current Medicinal Chemistry
March 1, 2009
Javier González-Maeso, Stuart C. Sealfon
74 citations
Seven transmembrane domain receptors, also termed G protein-coupled receptors (GPCRs), represent the most common molecular target for therapeutic drugs. The generally accepted pharmacological model for GPCR activation is the ternary complex model, in which GPCRs exist in a dynamic equilibrium between the active and inactive conformational states. However, the demonstration that different...
Current Medicinal Chemistry
October 1, 2002
Mark S. Levi, Ronald F. Borne
70 citations
Chemical substance abuse has tormented mankind throughout history. A number of chemical approaches have been employed in an attempt to treat chemical addiction. Unfortunately, most of these have proven unsuccessful though several chemical entities have been shown to be moderately effective. The naturally occurring alkaloid ibogaine has been reported to interrupt the cravings for alcohol,...