The serotonergic hallucinogen psilocybin has characteristic effects on human brain activity and subjective experience. Previous functional magnetic resonance imaging (fMRI) studies showed alternations of functional connectivity (FC) under the influence of psilocybin in humans. No study, as yet, investigated psilocybin-induced changes in brain hemodynamics and oxygenation with functional...
Die Erforschung des Schlafes ist von zentralem Interesse, sowohl aus theoretischen Gründen, da die Funktion des Schlafes teilweise immer noch unbekannt ist, als auch aus klinischer Sicht um die menschliche Gesundheit zu verbessern.Der Schlaf hat einen grossen Einfluss auf die Gesundheit, nicht nur aufgrund seiner Funktion was grundlegende kognitive Funktionen wie das Erinnerungsvermögen...
The experience of having a body is the key aspect for self-consciousness and it has been recognized that such a coherent bodily self relies on ongoing multisensory integration of bodily sensory inputs. A coherent bodily self is mostly taken for granted, despite being highly influenceable. To induce comparable bodily illusions in healthy participants, experimental paradigms have been developed...
Since the early 1990s, hallucinogenic drugs, such as psilocybin, have been increasingly used to investigate the neuronal basis of altered states of consciousness and psychosis. Furthermore, renewed interest has emerged in using these drugs as an adjunct to psychotherapy. Nevertheless, the therapeutic and experimental use of these substances is still controversial due to fears of potential harm....
Recent studies into the molecular, pharmacological and behavioral basis of psychotomimetics such as the glutamate N-methyl- D -aspartate receptor (NMDAR) antagonist ketamine and the mixed 5- hydroxytryptamine (5-HT) receptor agonist psilocybin in healthy human subjects suggest that both the glutamatergic and serotonergic system are implicated in the pathophysiolology of psychotic disorders such...
A nominal scale with 15 descriptive categories ordered in three general classes was designed. Being more complete than previous scales it captures systematically formal and content aspects of bizarreness. The data consisted of 39 REM-dream reports and 12 presleep waking fantasies (triggered by a stimulus scene) collected from 6 subjects in 12 experimental nights. The reports were rated by 4...