September 30, 2026
Abraham Peled
preprint
AbstractPsychiatry is the only branch of medicine that still diagnoses without reference to the organ it treats. Psychiatry: The Case for Starting Over argues that this is a structural failure rather than a temporary gap. The descriptive nosology inherited from Kraepelin and formalized in the DSM achieved diagnostic reliability at the cost of validity. Its categories were assembled by committee...
International Journal of Innovative Technologies in Social Science
September 28, 2026
Klaudia Karolina Wójcik, Michal Kieres, Krzysztof Sebastian Habirek et al.
The article aims to compare receptor mechanisms related to neurotransmitters for some of the most widely used psychoactive substances - amphetamine, cocaine, ecstasy (MDMA), and psilocybin - and to link these mechanisms to cardiovascular effects, thermoregulation, and neurotoxicity. The review is based mainly on in vitro studies on transporters and receptors, animal models, and controlled...
CNS Spectrums
September 28, 2026
Magda Malewska-Kasprzak, Filip Rybakowski, Monika Dmitrzak-Weglarz
Intravenous ketamine is a rapid-acting intervention for treatment-resistant depression (TRD) in adults with major depressive disorder and bipolar disorder (BD). While efficacy is established, a comprehensive integration of clinical, neurophysiological, biomarker, metabolic, and cognitive predictors remains lacking, limiting precision CNS-targeted therapy. To synthesize recent evidence on...
Zenodo (CERN European Organization for Nuclear Research)
September 26, 2026
Douwe Fennema
preprint
Abstract During wakefulness, experience continually changes the functional organization of neural networks. Repetition, attention, emotional significance, and other forms of experience-dependent activation can affect the relative strength of synaptic relationships (Hebb, 1949; Bliss & Lømo, 1973; Dudek & Bear, 1992). During sleep, direct coupling to external sensory input and behavioral output...
Zenodo (CERN European Organization for Nuclear Research)
September 26, 2026
Alessandro Mahony
preprint
L'Analogic Meditation (AM) è una pratica meditativa strutturata che integra visualizzazione simbolica, suggestione ideoplastica e lavoro sul corpo-mente, sviluppata da Alessandro Mahony nell'ambito di un approccio psiconeurosomatico integrato. A oggi, l'AM non è stata oggetto di studi clinici nella Sclerosi Laterale Amiotrofica (SLA). Tuttavia, sulla base delle conoscenze neurobiologiche...
Zenodo (CERN European Organization for Nuclear Research)
September 26, 2026
Alessandro Mahony
preprint
Analogic Meditation (AM) is a structured meditative practice that integrates symbolic visualization,ideoplastic suggestion, and body-mind work, developed by Alessandro Mahony withinan integrated psychoneurosomatic approach. To date, AM has not been the subject of clinicalstudies in Amyotrophic Lateral Sclerosis (ALS). However, based on current neurobiologicalknowledge on meditation, hypnosis,...
Mindfulness
September 25, 2026
Senyao Du, Guowen Ai, Shiao Zhao et al.
Proprioception is crucial for physical activities, motor control, balance, and coordination, yet strategies to enhance it remain debated. Mindfulness-based interventions (MBIs) may improve proprioception by enhancing body awareness through attention regulation and body-mind synergy. MBIs offer low intensity, low cost, and good repeatability. This study hypothesized that MBIs improve...
Journal of Education, Health and Sport
September 24, 2026
Anna Kamosińska, Julia Pająk, Olga Sławatyniec et al.
Treatment-resistant depression (TRD) in adolescents remains a major clinical challenge because of the limited efficacy of conventional antidepressants and the high risk of suicidal behavior. Ketamine has emerged as a rapidly acting antidepressant with a unique glutamatergic mechanism, promoting neuroplasticity and reducing neuroinflammation. Clinical studies demonstrate significant symptom...
npj Science of Learning
September 23, 2026
Yong Huang, Jia-Hui Guo, Shuai Zheng et al.
Abstract The effects of brief mindfulness meditation (BMM) on attention networks remain unclear. Using Event-Related Potentials (ERPs), this study investigated how 18 days of Anapanasati meditation (JW2016 mental exercises, 15 min/day) modulates attentional functions in healthy adults. Behaviorally, BMM produced a selective enhancement of the executive control network, evidenced by...
Journal of Personalized Medicine
September 23, 2026
Aleksandra Metelska, Wojciech Ziemichód, Hanna Karakuła-juchnowicz
Objectives: A significant problem in the treatment of depressive disorders is the growing number of cases of so-called treatment-resistant depression (TRD). There is evidence of ketamine’s effectiveness in treating TRD, with response rates ranging from 40% to 90%. This review aimed to map available studies on peripheral biomarkers of response to ketamine and esketamine in the treatment of...