Research Square
October 29, 2026
Jiaojian Wang, Jin Chen, Wenjie Sun et al.
preprint
Abstract Psilocybin holds strong therapeutic promise for treating major depressive disorder. However, the cellular and molecular substrates underlying its action have not been fully elucidated, especially in the primate brain. We combined multimodal MRI, magnetic resonance spectroscopy (MRS), cerebrospinal fluid (CSF) proteomics and metabolomics, and single-nucleus RNA sequencing (snRNA-seq) to...
Brain Sciences
October 29, 2026
Adela G. Buciuc, Mark S. Gold, Brian S Fuehrlein
Substance use disorders remain a leading cause of preventable death, and existing care is better described as disease management than as cure. Medications for opioid, alcohol, and tobacco use disorders reduce substance use, and opioid agonist treatment reduces mortality, yet retention is poor and functional recovery is rarely measured. This review asks whether psychedelics treat addiction, or...
Molecular Psychiatry
October 28, 2026
Haojiang Zhai, Hongshuang Wang, Yibo Wang et al.
Serotonergic psychedelics have revitalized psychiatric research by producing rapid and potentially sustained clinical benefits in selected neuropsychiatric conditions. However, the mechanisms linking receptor activation to neural plasticity, altered conscious experience, and clinical improvement remain incompletely understood, while the evolutionary origins of psychedelic signaling and the...
Revista Foco
October 28, 2026
Rhanna Mickelly Moreno Do Nascimento, Emily Lobo Ferreira da Silva, Vitor Duarte Falci et al.
A depressão maior resistente ao tratamento configura um importante desafio clínico e de saúde pública, caracterizado pela ausência de resposta satisfatória a esquemas terapêuticos convencionais. Diante das limitações dos antidepressivos tradicionais, a psilocibina tem sido investigada como alternativa terapêutica promissora, especialmente quando administrada em ambiente clínico controlado e...
bonndoc
October 26, 2026
Yara Mecdad
Autophagy is a fundamental cellular process critical for maintaining homeostasis and has emerging relevance in stress adaptation and affective disorders. This thesis investigated how autophagy flux is modulated by acute stress, chronic stress-associated depression, pharmacological interventions, and psychedelic compounds across human, mouse, organotypic and cellular models. In humans, acute...
CRC Press eBooks
October 26, 2026
Michele di Salvo
Charles Bonnet syndrome (CBS) represents a profound and paradoxical neurological condition, a crossroads between ophthalmology, neurology, and the philosophy of mind, in which vivid, complex, and often spectacular visual hallucinations occur in neurologically and psychiatrically healthy individuals, in response to significant vision loss. This narrative-style scientific chapter aims to explore...
Zenodo (CERN European Organization for Nuclear Research)
October 24, 2026
Rakesh Chandola
preprint
Background: The philosophy of medicine has undergone a profound paradigm shift over millennia. In ancient India, health was conceptualized through a holistic framework where the mind (Manas), body (Sharira), and spirit (Atman) were viewed as an indivisible continuum. Conversely, Western modern medicine historically embraced Cartesian dualism rigidly separating physical pathology from...
University of the Sunshine Coast
October 22, 2026
Cyrana C. Gallay
Suicide is an urgent public health concern and a leading cause of death, globally. Chronic suicidality may be described as persistent or recurrent suicidal ideation presenting over periods of months to years. While suicidality is associated with a complex range of proximal and distal risk factors, there is no single set of clinical features accurately able to predict development. Limited...
Frontiers in Molecular Neuroscience
October 21, 2026
Zuzanna Sulej, Magdalena Zielińska
Ketamine has revolutionized psych iatric treatment, challenging monoamine-based paradigms through its capacity for rapid antidepressant action. While N-methyl-D-aspartate receptor (NMDAR) antagonism remains the canonical mechanism, this integrative review proposes a multi-receptor, neuron–glia convergence model to help account for ketamine's therapeutic efficacy. We outline the well-established...
Zenodo (CERN European Organization for Nuclear Research)
October 20, 2026
Lara Vervloet Carvalho, Sarah Isabela Magalhães Costa, Nathália Marques Santos et al.
preprint
As terapias assistidas por psicodélicos emergiram, na última década, como estratégia de investigação de destaque para transtornos psiquiátricos refratários às abordagens convencionais. Em ensaio de fase 2 controlado, dose única de 25 mg de psilocibina produziu redução média de 12,0 pontos na escala MADRS em pacientes com depressão resistente ao tratamento, superior à condição controle de 1 mg....