International Journal of Innovative Technologies in Social Science
September 21, 2026
Mateusz Gawin, Emilia Koziara, Mateusz Gadzina et al.
Major depressive disorder (MDD) is one of the leading causes of disability worldwide. A substantial proportion of patients fail to achieve remission through standard monoaminergic therapies, meeting the clinical criteria for treatment-resistant depression (TRD). TRD is associated with significant clinical morbidity and a profound economic burden on healthcare systems. This review evaluates the...
Expert Opinion on Therapeutic Targets
September 21, 2026
Sixtine Fleury, Katherine M. Nautiyal
INTRODUCTION: Depressive and anxiety disorders impose a substantial public health burden, yet current serotonergic therapies are limited by delayed onset, modest remission rates, and adverse side effects. Here we put forward the serotonin 1B receptor (5-HT1BR) as an important therapeutic target for mood related pathology. AREAS COVERED: We synthesize converging evidence from human and...
Zenodo (CERN European Organization for Nuclear Research)
September 19, 2026
Wolfgang Stegemann
preprint
The traditional comparison between biological brains and artificial systems is becoming increasingly difficult to sustain in terms of individual properties. Artificial networks can exhibit recurrence, plasticity, critical or near critical dynamics, metastable behavior, high dimensional population activity, adaptive responses, and large scale connectivity. Whole brain simulations have reached...
Mini-Reviews in Medicinal Chemistry
September 18, 2026
Fatemeh Abolhasani, Hojjat Rezaiezadeh, Mohammad Amin Langarizadeh et al.
Psilocybin, a compound found in certain species of Psilocybe mushrooms, shows potential as a treatment for various psychiatric conditions. In the past decade, a growing body of evidence has shown the effectiveness of psilocybin in treating conditions, such as treatment-resistant depression, generalized anxiety disorder, post-traumatic stress disorder, and substance use disorders. This review...
bioRxiv (Cold Spring Harbor Laboratory)
September 18, 2026
Aurora Savino, Carla Liaci, Giorgio R. Merlo et al.
preprint
Background Classic psychedelics are serotonergic agents increasingly recognized for their ability to produce rapid and long-lasting therapeutic effects in several neuropsychiatric conditions, yet the molecular mechanisms that translate acute serotonergic perturbation into long-term brain adaptation remain poorly understood. Psychedelic action is commonly attributed to enhanced neuronal...
Cells
September 17, 2026
Katarzyna Lipke, Agnieszka Piwowar
Formerly recognized as an opioid receptor, the sigma-1 receptor (σ1R) is a multifunctional chaperone protein that plays a crucial role in regulating neuronal signaling, neuroprotection, and synaptic plasticity. Increasing evidence highlights a tight functional association between the σ1R and the N-methyl-D-aspartate receptor (NMDAR), a central mediator of excitatory neurotransmission and...
Molecular Psychiatry
September 17, 2026
James J Gattuso, Bilgenur Bezcioglu, Jenna Hendey et al.
Obsessive-compulsive disorder (OCD) remains difficult to treat, and evidence indicates that social dysfunction, common across obsessive-compulsive and related disorders, is an under-recognized clinical burden. SAPAP3 knockout (KO) mice, a well-established model of compulsive behavior, exhibit social abnormalities, suggesting broader disruptions in circuits relevant to social cognition. Here, we...
Clinical Psychopharmacology and Neuroscience
September 16, 2026
Shih‐Hsien Lin, Muhammad Abdullah, Huai‐Hsuan Tseng et al.
Objective: Mindfulness is an effective non-pharmacological intervention for mental health.However, little is known about the underlying neurological mechanisms involved, especially glutamate, -aminobutyric acid (GABA), and the excitation-inhibition (E-I) balance.This study examined changes in these markers after mindfulness training and whether these changes are related to the baseline...
Journal of Multiscale Neuroscience
September 15, 2026
M. Dobeš
Whole-brain models of Drosophila melanogaster have progressed from connectome-constrained simulation to neuromorphic implementation and closed-loop embodiment. This progress creates an ethical question that is no longer purely hypothetical: could large numbers of such emulations instantiate negatively valenced states? We argue that the answer is presently indeterminate. The target is valence -...
European Journal of Pharmacology
September 15, 2026
Anna Brancato, Martina Cicero, Valentina Castelli et al.
Stress is a major determinant of psychopathology, with coping and cognitive impairment arising from abnormal glucocorticoid activity and brain-derived neurotrophic factor (BDNF)-dependent neuroplasticity in the hippocampus. The endocannabinoid system modulates stress and hippocampal functioning since early development, thus its early-life disruption may program vulnerability to stress-related...