Preprints.org
October 19, 2026
Maxwell Jackson Harrell
preprint
The transmission of consciousness through a chemical synapses is an under-specified probable occurrence. Chemical transmission is essential for neuronal propagation and neural propagation is essential within many existing measurements of consciousness. The development and plasticity of consciousness throughout an animal's lifetime requires grounded chemical distinctions, executive and...
Diálogos Interdisciplinares em Psiquiatria e Saúde Mental
October 19, 2026
Letícia Macedo Pinto, Lucas Macedo Pinto, Joel Porfírio Pinto
Introduction: Obsessive-Compulsive Disorder (OCD) presents approximately 20% of cases refractory to conventional treatments, driving the investigation of pathophysiological pathways, including the glutamatergic hypothesis. In this context, ketamine emerges as a potential intervention. This study reviewed the literature on ketamine use in OCD, focusing on efficacy, mechanisms, and safety....
Journal of Neurotrauma
October 19, 2026
Hoda K AbouEich, Ali Izadi, Jonathan Lifshitz et al.
There are currently no available effective pharmacological therapies for treating chronic cognitive deficits after traumatic brain injury (TBI). Psychoplastogens, including atypical psychedelics, classical serotonergic psychedelics, and neuroplastogens, are a class of small molecule drugs that can enhance neuroplasticity by inducing rapid and sustained effects on neuronal architecture and...
CNS & Neurological Disorders - Drug Targets
October 14, 2026
Sheekha Chaudhary, Sanchit Dhankhar, Monika Saini et al.
More than fifty million individuals worldwide are experiencing neurodegenerative disorders, which include Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis, Huntington's disease, multiple sclerosis, and frontotemporal dementia. These disorders have a significant role in the gradual degradation of cognition and motor skills. Most current treatment approaches have little...
arXiv Preprint Archive
October 14, 2026
Victor Oswald, David Zarka, Riku Johannes Ihalainen et al.
preprint
How mental training reshapes the temporal architecture of large-scale brain dynamics and how these mechanisms differ between healthy and clinically vulnerable populations remains poorly understood. Time-averaged neural measures collapse the multi-scale nature of brain activity, obscuring the dynamic processes through which behavioural interventions reorganise hierarchical brain function. Here,...
Advances in Therapy
October 14, 2026
Ahmed I Anwar, Abdul-Rahman A Hegazi, M Farris Sawaya et al.
Substance use disorders (SUDs) are a major global health burden, and psychedelic-assisted therapies are now gaining scientific interest, with ibogaine being considered as a candidate for anti-addictive effects across multiple substance classes. Ibogaine is a multi-target indole alkaloid acting on opioid, glutamatergic, serotonergic, and sigma systems with potential to rapidly reduce withdrawal...
bioRxiv (Cold Spring Harbor Laboratory)
October 13, 2026
Claudio Agnorelli, Joseph Peill, Danielle Kurtin et al.
preprint
Neuroplasticity, the brain's capacity to reorganise its structure and function, is a transdiagnostic feature across psychiatric and neurodegenerative diseases and a putative mechanism of action for pharmacological interventions. [11C]-UCBJ positron emission tomography (PET), which quantifies synaptic vesicle glycoprotein 2A (SV2A) density, offers the most direct in vivo measure of human...
Asian Journal of Psychiatry
October 12, 2026
Gia Han Le, Sabrina Wong, Simryn Selby et al.
Ketamine is a rapid-acting antidepressant with demonstrated efficacy in major depressive disorder and treatment-resistant depression, yet the mechanisms by which its molecular actions translate into sustained clinical improvement remain incompletely understood. Prevailing models have emphasized N-methyl-D-aspartate receptor antagonism and downstream glutamatergic signaling; however, convergent...
Journal of Molecular Neuroscience
October 12, 2026
Meitar Grad, Hadas Volkov, Noam Shomron
Abstract Major depressive disorder (MDD) is a prevalent psychiatric disorder, and is a leading cause of disability worldwide. Current treatments for MDD entail many side effects, and include a lag until the onset of therapeutic effects. The current hypotheses as for the etiology of MDD revolve around the monoamine hypothesis and the plasticity and neurodegeneration hypothesis. According to the...
Psychiatry and Clinical Psychopharmacology
October 11, 2026
Kim Supit, Giordano N. Rossi, José Augusto S. Reis et al.
Background: Classic psychedelics, including LSD, psilocybin, and N,N-dimethyltryptamine (DMT)/ ayahuasca, have shown promise as rapid-acting treatments for psychiatric disorders. Because sleep plays a central role in emotional regulation and neuroplasticity, psychedelic-induced changes in sleep architecture are of interest.Methods: A systematic review was conducted following PRISMA guidelines....