Neuroscience
January 26, 2026
Batoul Darwish, Jad El Masri, Lina Hourieh et al.
Neurogenesis in the adult brain is a precisely regulated process that remains highly sensitive to intrinsic and extrinsic influences. Among the external factors are psychological conditions, such as post-traumatic stress disorder (PTSD), which arises after exposure to trauma such as war, accidents, violence, or natural disasters. PTSD, as well as other disorders like stress and depression, has...
Neuron
January 7, 2026
Jinsu Lee, Michael A. Wheeler
The lifetime prevalence of mood disorders such as major depressive disorder (MDD) is thought to approach up to 50% of the world's population. Traditionally, research into the mechanisms of these disorders has focused on neurotransmission, but emerging evidence highlights neuroimmune interactions-the molecular signaling between immune and brain cells-as key regulators of brain plasticity,...
2026
Irina Dell'Orto
preprint
Background: Psilocybin-assisted therapy (PAT) has demonstrated rapid and substantial antidepressant effects in phase 2 RCTs (Davis et al., 2021; Carhart-Harris et al., 2021), and phase 3 trials are now active (Usona uAspire, NCT06308653). However, three critical gaps remain unresolved in 2025: (1) the durability of effects beyond 12 months has not been established in a controlled design; (2)...
2026
Abigail E. Calder
A growing number of studies suggest that serotonergic psychedelics, including lysergic acid diethylamide (LSD), can rapidly and lastingly stimulate various aspects of neuroplasticity. Neuroplasticity is the nervous system’s fundamental ability to reorganize itself in order to adapt to its environment, and it involves both changes in brain structure and changes in how the brain functions. It is...
International Journal of Clinical and Experimental Hypnosis
2026
Eleonora Malloggi, Enrica L Santarcangelo
High hypnotizability predicts greater similarity between the cortical correlates of actual and imagined action (functional equivalence, FE). The study investigated whether motor imagery (MI) training (MIT) improves subjective experience, chronometric indices, and the EEG correlates of MI (like physical training), and whether absorption, imagery abilities, and interoceptive sensibility influence...
Open Mind
2026
Alexi Mary Theofanous
preprint
Recent research into psychedelic-assisted psychotherapy has largely emphasised pharmacological mechanism such as neuroplasticity and symptom reduction, with less attention to the relational processes through which therapeutic change is supported and integrated. Given that such experiences are central to therapeutic change, this introduces a significant limitation: variability in therapist...
Frontiers in Pharmacology
2026
Patricio Sáez-briones, Amanda Silva-Rodríguez, Michelle Morales-Vidal et al.
In humans, empathy is expressed through various prosocial behaviours between individuals that may be enhanced after intake of the synthetic entactogen MDMA (3,4-methylenedioxymethamphetamine, "Ecstasy") as the behavioural expression of the so-called entactogenic syndrome. Rodents may also exhibit empathy-like behaviours, such as social interaction and helping behaviour. In this regard, while...
OPUS FAU - Online publication system of Friedrich-Alexander-Universität Erlangen-Nürnberg
2026
Aneta Petrušková
INTRODUCTION: Sertonergic psychedelics LSD, psilocin and DMT, have been shown to hold a great potential for treatment of various neuropsychiatric conditions, such as major depressive disorder, addiction, and end-of-life anxiety. Effects of these substances on neuronal activity and plasticity have been demonstrated, however, better understanding of their mechanism of action is crucial for...
Advanced Neurology
December 4, 2025
Taslim Uddin, Sharmin Akter, Kaustabh Ghosh
Psychedelics are gaining recognition for their effectiveness as modulators of neuroplasticity in the treatment of a range of neuropsychiatric disorders. Psilocybin, lysergic acid diethylamide, N,N-dimethyltryptamine, and ketamine are substances that mainly affect the serotonergic and glutamatergic systems. They induce rapid synaptogenesis, dendritic remodeling, and changes in functional...
Alzheimer s & Dementia
December 1, 2025
Leelavathi N. Madhu, Yogish Somayaji, Sanya Kotian et al.
Abstract Background Chronic neuroinflammation plays a significant role in Alzheimer’s disease (AD) pathogenesis associated with a decline in cognitive and mood function. Currently, there are no effective therapies to alleviate the progression of brain dysfunction in AD. Psilocybin, an FDA‐approved drug for treating major depressive disorder, can restrain neuroinflammation and improve...