Nature Neuroscience
September 1, 2025
Isak K Aarrestad, Lindsay P. Cameron, Ethan M Fenton et al.
Nonhallucinogenic psychoplastogens, such as tabernanthalog (TBG), are being developed as potentially safer, more scalable alternatives to psychedelics for promoting neuronal growth and treating various brain conditions. Currently, it is unclear whether 5-hydroxytryptamine 2A (5-HT2A) receptors and immediate early gene (IEG) activation have a role in the neuroplasticity-promoting effects of...
Frontiers in Psychiatry
September 1, 2025
Ronit Kishon, Yael M. Cycowicz
The resurgence of interest in psychedelic compounds as potential treatments for psychiatric disorders represents a paradigm shift in mental health care. Psychedelics exert their effects through serotonergic modulation, particularly via 5-HT2A receptor activation, inducing profound alterations in consciousness and catalyzing neuroplasticity. While their neurobiological effects are...
Molecular Psychiatry
August 23, 2025
Adam J. Drewko, Ron L. P. Habets, Tibor M Brunt
4 citations
Serotonergic psychedelics, including the recreationally used psilocybin and LSD, have become promising therapeutic agents for the treatment of treatment-resistant depression. While it is generally agreed that they exhibit their antidepressant effects by inducing rapid and sustained neuroplasticity, the molecular mechanisms responsible are widely debated. In particular, the role of the serotonin...
bioRxiv Preprint Server
July 23, 2025
Tomas Del Olmo, Mathilde Decourcelle, Martial Séveno et al.
preprint
The serotonin (5-HT)2A receptor is the primary target of numerous psychoactive drugs including serotonergic psychedelics, and mediates psychedelics-induced neuroplasticity, but the signaling mechanisms involved remain poorly characterized. Using quantitative phosphoproteomics, we show that the administration of the hallucinogenic 5-HT2A receptor agonist 2,5-dimethoxy-4-iodoamphetamine (DOI) to...
bioRxiv
July 7, 2025
Vasil Kolev, Kosio Beshkov, Peter Malinowski et al.
1 citation
preprint
The objective of the present study was to characterize the effects of long-term meditation (LTM) on directed connectivity patterns during resting-state and meditative brain states. Specifically, it was aimed to identify major cortical sources of information flow and target regions of information influx, and to reveal which frequency-specific oscillatory networks are critically involved in...
Философская мысль
July 1, 2025
A. V. Safronov
The subject of the study is phenomenological neuroplasticity, considered as a key biological mechanism that ensures the emergence and development of consciousness. The object of the research is the process of forming subjective phenomenal experience, realized through the dynamic restructuring of neural networks in the brain. Special attention is given to the evolutionary role of...
International Immunopharmacology
June 26, 2025
Salma Laabi, Claire LeMmon, Callie Vogel et al.
15 citations
Psilocybin, a serotonergic psychedelic, has demonstrated therapeutic potential in neuropsychiatric disorders. While its neuroplastic and immunomodulatory effects are recognized, the underlying mechanisms remain unclear. This study investigates how psilocybin and its active metabolite, psilocin, influence microglial inflammatory responses and neurotrophic factor expression through serotonergic...
Psychoactives
June 23, 2025
Georgios Mikellides
7 citations
Ketamine and esketamine are two closely related compounds with fast-acting antidepressant properties that have reshaped the treatment landscape for individuals with treatment-resistant depression (TRD). Originally developed as anesthetic agents, both have since demonstrated rapid and robust antidepressant effects in patients who have not responded to conventional treatments such as selective...
bioRxiv : the preprint server for biology
June 15, 2025
Michael Von Gunten, Tenna Russell, Isaac Stirland et al.
preprint
Psychedelics are emerging as a promising treatment option for a range of neuropsychiatric disorders, including substance use disorders. One potential mechanism underlying their therapeutic benefits may involve a reversal of maladaptive plasticity induced by drug exposure. Here, we identify physiological, behavioral, and epigenetic impacts of lysergic acid diethylamide (LSD) on morphine-treated...
Molecular Neurobiology
June 5, 2025
Lucas C. Santos, Fernanda Dos Santos Petry, Carolina Saibro-Girardi et al.
4 citations
Stress is widely recognized as a major environmental factor contributing to the development of mood disorders. In patients with Major Depressive Disorder (MDD) and suicidal behavior, significant hyperactivation of the hypothalamic-pituitary-adrenal (HPA) axis is observed, characterized by excessive cortisol release, which in turn stimulates the production of pro-inflammatory mediators....