Neuroplasticity: all studies (page 4) - The Consciousness Library

Harnessing Neural Resiliency: A Comprehensive Review of Emerging Neuroplasticity Promoters and Their Clinical Efficacy in Depression Management

JOURNAL OF ADVANCE AND FUTURE RESEARCH April 1, 2026 Ashish Yadav, Ravina Yadav

Major depressive disorder (MDD) is a complex psychiatric condition associated with alterations in brain neuroplasticity. Brain-derived neurotrophic factor (BDNF), a key regulator of neuronal survival, synaptic plasticity, and neurogenesis, has been widely studied as a biological marker of neuroplasticity in depression. This review and meta-analysis evaluated the relationship between BDNF levels...

DOI: 10.56975/jaafr.v4i4.508090 Full text Neuroplasticity Major depressive disorder Treatment-resistant depression Synaptic plasticity +13

Psilocin fosters neuroplasticity in iPSC-derived human cortical neurons.

Elife March 27, 2026 Målin Schmidt, Anne Hoffrichter, Mahnaz Davoudi et al. 3 citations

Psilocybin is studied as innovative medication in anxiety, substance abuse and treatment-resistant depression. Animal studies show that psychedelics promote neuronal plasticity by strengthening synaptic responses and protein synthesis. However, the exact molecular and cellular changes induced by psilocybin in the human brain are not known. Here, we treated human cortical neurons derived from...

DOI: 10.7554/elife.104006 Full text 5-ht2a receptor Psilocin Neuroplasticity Bdnf +2

Beyond the Genomic Storm: Evaluating Tabernanthalog as a Potential Scaffold for Silent Neuroplasticity and Broad-Spectrum Therapy

International Journal of Molecular Sciences March 20, 2026 Ivan Anchesi, Ivana Raffaele, M. Astorino et al.

The clinical renaissance of psychedelic medicine has highlighted the therapeutic potential of rapid-acting neuroplastogens, or "psychoplastogens," for psychiatric disorders. However, the widespread application of classical psychedelics-such as psilocybin and LSD-and the atypical dissociative ibogaine is severely limited by their hallucinogenic properties and, particularly in the case of...

DOI: 10.3390/ijms27062811 Neuroplasticity Synaptic plasticity Cognition Schizophrenia object-oriented programming +7

Pharmacological regulation of adult brain neuroplasticity: Synergistic roles of neuropeptide signaling, psychedelics, and synaptic modulators.

Molecular and cellular neurosciences March 1, 2026 Mustafa M Shokr, Mohamed N Fawzy, Ahmed M Abdelaziz

Neuroplasticity refers to the ability of the brain to modify synaptic connections and reorganize neural circuits, underpinning cognitive function, emotional regulation, and recovery from injury. Recent advances have redefined adult neuroplasticity as more dynamic and therapeutically accessible than previously thought, spurring investigation into pharmacological interventions that can augment...

DOI: 10.1016/j.mcn.2026.104076 Full text Neuroplasticity Ampa receptor trafficking Multi-omics modeling Nitric oxide signaling +1

Psychedelic neuroplasticity of cortical neurons lacking 5-HT2A receptors

Molecular Psychiatry March 1, 2026 Tyler G. Ekins, Chloe Rybicki-Kler, Tao Deng et al. 9 citations

Classical psychedelic drugs show promise as a treatment for major depressive disorder and related psychiatric disorders. This therapeutic efficacy stems from long-lasting psychedelic-induced neuroplasticity onto prefrontal cortical neurons and is thought to require the postsynaptic expression of serotonin 2A receptors (5-HT_2AR). However, other cortical regions such as the granular...

DOI: 10.1038/s41380-025-03257-w Full text

The Role of Psychedelics in Maintaining Neuroplasticity During Aging

Zenodo (CERN European Organization for Nuclear Research) February 28, 2026 Somkin Kyrylo preprint

Psychedelic compounds such as LSD and Psilocybin have historically been classified alongside illicit substances and widely regarded with skepticism. However, emerging neuroscientific evidence suggests that certain psychedelics may function as “psychoplastogens”- compounds capable of promoting structural and functional neural plasticity. Recent preclinical and early clinical studies indicate...

DOI: 10.5281/zenodo.18814038

Delayed psilocybin treatment after repeated mild traumatic brain injury recovers chronic behavioural deficits, reduces microglial density, and enhances hippocampal neurogenesis in rats

Research Square February 23, 2026 Sandy R Shultz, Josh Allen, Grace O'Regan et al. preprint

Abstract Repeated mild traumatic brain injury (RmTBI) can produce lasting cognitive, emotional, and social deficits (e.g., persistent post-concussion symptoms; PPCS). Despite the prevalence of RmTBI in sports, military, and domestic violence settings, effective treatments to alleviate the neurological consequences of RmTBI remain limited. Psilocybin, a serotonergic psychedelic, can enhance...

DOI: 10.21203/rs.3.rs-8555503/v1 Psilocybin Neuroplasticity Serotonergic Neurogenesis +12

Psychedelics and the Extracellular Matrix: Rewiring Neuroplasticity and Metaplasticity for Next-Generation Psychiatric Therapies

Biological Psychiatry February 1, 2026 Jin Zhang, Cong Lin, Xinyou Lv et al. 1 citation

Classic psychedelics, such as psilocybin, lysergic acid diethylamide (LSD), and N,N-dimethyltryptamine (DMT), have emerged as potent modulators of neuroplasticity and metaplasticity in the adult brain, offering novel therapeutic strategies for neuropsychiatric disorders. Recent findings reveal that beyond their transient psychotropic effects, these compounds activate serotonin 5-HT2A receptors...

DOI: 10.1016/j.biopsych.2026.02.011 Neuroplasticity Synaptic plasticity Perineuronal net Regulator +6

Psilocybin-Induced Neuroplasticity and Sustained Antidepressant Effects

Quality in Sport January 31, 2026 Anna Maria Komarczewska, Filip Matusiak, Klaudia Brzoza et al.

Psilocybin-assisted interventions have shown rapid reductions in depressive symptoms in controlled clinical settings, raising questions about biological mechanisms supporting durability beyond the acute drug effect. [5,7] Mechanistic accounts increasingly focus on neuroplasticity as a candidate pathway linking transient serotonergic receptor activation to longer-lasting psychological and...

DOI: 10.12775/qs.2026.51.68216 Neuroplasticity Serotonergic Antidepressant Psychological intervention +8

Single-dose DMT reverses anhedonia and cognitive deficits via restoration of neurogenesis in a stress-induced depression model.

Translational Psychiatry January 29, 2026 Rafael V Lima Da Cruz, Rêmullo B. G. De Miranda Costa, Gabriel M. De Queiroz et al. 2 citations

Major depressive disorder (MDD) remains a leading cause of disability worldwide, with current treatments limited by delayed onset and low efficacy. The serotonergic psychedelic N,N-dimethyltryptamine (DMT) has shown rapid antidepressant effects in early clinical studies, yet its mechanisms and efficacy remain poorly characterized in established models of depression. Here, we evaluated the...

DOI: 10.1038/s41398-026-03852-7 Full text