Neuroplasticity: all studies (page 34) - The Consciousness Library

Acute ketamine enhances social behavior and dendritic plasticity in the amygdala by increasing BDNF, GAP43, and TRKB presence following excitotoxic neonatal ibotenic acid lesion.

Neurochemistry International July 1, 2025 Nestor I Martínez-Torres, Jhonathan Cárdenas-Bedoya, Blanca Miriam Torres-Mendoza

Schizophrenia is a highly disabling psychopathology that is a significant burden on public health systems and is characterized by both positive and negative symptoms. One of these negative symptoms is social isolation, which responds poorly to available treatments. Ketamine (KET) has been shown to enhance social behavior in various preclinical models, accompanied by neurobiological changes. In...

DOI: 10.1016/j.neuint.2025.106016 Full text Brain plasticity Bdnf Gap43 Trkb +10

Neurobehavioral and Molecular Pharmacology of Pharmahuasca ($\textit{N,N}$-dimethyltryptamine (DMT) and Harmine) in Humans – A Combined Neuropharmacological and Brain Imaging Approach

June 4, 2025 Klemens Egger

Over the past decade, research with psychedelics has gained new momentum, leading to a psychedelic renaissance in both basic and clinical research. Among these substances is ayahuasca, an Amazonian plant medicine used for millennia by indigenous people for ritualistic and healing practices, which has recently entered research labs in the Americas and Europe. Preliminary findings indicate its...

DOI: 10.5167/uzh-278132 Full text Neuroplasticity Psychedelic medicine Mental health treatment Brain imaging

Neurotransmitter-related functional connectivity changes in serotonin and dopamine systems after mindfulness in medication overuse headache.

Cephalalgia June 1, 2025 Davide Fedeli, Giuseppe Ciullo, Greta Demichelis et al. 7 citations

Background/HypothesisMindfulness practice has gained attention in managing chronic migraine with medication overuse headache (CM-MOH), showing clinical improvements and functional connectivity reorganization. However, the relationship between these effects and the underlying neurotransmitter systems remains unexplored.MethodsThirty-four CM-MOH patients were divided into treatment as usual (TaU,...

DOI: 10.1177/03331024251332561 Full text Meditation Neuroplasticity Serotonin Medication overuse headache +21

Molecular pathways of ketamine: A systematic review of immediate and sustained effects on PTSD.

Psychopharmacology June 1, 2025 Nathan J Wellington, Ana P. Bouças, Jim Lagopoulos et al. 16 citations

Existing studies predominantly focus on the molecular and neurobiological mechanisms underlying Ketamine's acute treatment effects on post-traumatic stress disorder (PTSD). This emphasis has largely overlooked its sustained therapeutic effects, which hold significant potential for the development of targeted interventions. This systematic review examines the pharmacokinetic and pharmacodynamic...

DOI: 10.1007/s00213-025-06756-4 Full text Ketamine PTSD Synaptic plasticity Trauma-therapy +9

Effects of serotonergic psychedelics on synaptogenesis and immediate early genes expression - comparison with ketamine, fluoxetine and lithium.

Journal of Psychopharmacology May 28, 2025 Yana Vella, Kateřina Syrová, Aneta Petrušková et al. 1 citation

Recent evidence suggests that psychedelics can induce rapid and long-lasting antidepressant effects. The generally acknowledged explanation for these traits is the phenomenon of neuroplasticity, although the exact underlying molecular mechanisms remain unclear. This study investigates the effects of psilocin, lysergic acid diethylamide (LSD) and N,N-dimethyltryptamine (DMT) on synaptogenesis...

DOI: 10.1177/02698811251338232 Full text DMT LSD Neuroplasticity Ketamine +5

The Potential Role of Psilocybin in Traumatic Brain Injury Recovery: A Narrative Review

Brain Sciences May 26, 2025 Charles Palmer, Ally T Ferber, Brian D Greenwald 4 citations

Background: This narrative review explores psilocybin’s potential use as a therapeutic agent in patients with traumatic brain injury (TBI). Methods: We engaged in a search of PubMed, ScienceDirect, and Cochrane’s databases for information on the effects of psilocybin. We also reviewed articles where psilocybin was used in patients with TBI. Articles from 2000–2025 were included. Results: A...

DOI: 10.3390/brainsci15060572 Neurogenesis Neuroplasticity Medical psilocybin Traumatic brain injury +12

Bioactive ketamine metabolite exerts in vivo neuroplastogenic effects to improve hippocampal function in a treatment-resistant depression model.

Cell Reports May 21, 2025 Lace M Riggs, Sage Aronson, Ta-Chung M. Mou et al. 2 citations

An acute increase in excitatory synaptic transmission contributes to the rapid antidepressant actions of neuroplastogens, including ketamine and its bioactive metabolite, (2R,6R)-hydroxynorketamine (HNK). It is hypothesized that drug-induced metaplastic changes in synaptic strength account for therapeutically relevant behavioral adaptations in vivo. Using the plasticity-deficient Wistar Kyoto...

DOI: 10.1016/j.celrep.2025.115743 Full text Synaptic plasticity Treatment-resistant depression Cp: neuroscience Wistar kyoto +6

Separate or inseparable? Serotonin and dopamine system interactions may underlie the therapeutic potential of psilocybin for anorexia nervosa

Physiology & Behavior May 20, 2025 Kaspar McCoy, Felicia Reed, Kyna‐anne Conn et al. 4 citations

Psilocybin, a serotonergic psychedelic, has emerged as a promising treatment for a range of mental health conditions, including anorexia nervosa. Recent insights from animal models and human imaging studies suggest psilocybin enhances cognitive flexibility and modifies reward processing - two core processes disrupted in anorexia nervosa. Both cognitive flexibility and reward processing are...

DOI: 10.1016/j.physbeh.2025.114957 Psilocybin Serotonergic Neuroplasticity Anorexia nervosa +6

Ketamine rescues anhedonia by cell-type- and input-specific adaptations in the nucleus accumbens.

Neuron May 7, 2025 Federica Lucantonio, Jacob Roeglin, Shuwen Li et al. 24 citations

Ketamine is recognized as a rapid and sustained antidepressant, particularly for major depression unresponsive to conventional treatments. Anhedonia is a common symptom of depression for which ketamine is highly efficacious, but the underlying circuits and synaptic changes are not well understood. Here, we show that the nucleus accumbens (NAc) is essential for ketamine's effect in rescuing...

DOI: 10.1016/j.neuron.2025.02.021 Full text Brain plasticity Synaptic plasticity Neuroscience research Reward circuits +10

Role of CaMKII/CREB pathway in rapid-antidepressant-like effect: comparison of ketamine with rapastinel.

Experimental Brain Research May 4, 2025 Ceyda Özler, Esra Özkan, Narges Shomalizadeh et al. 1 citation

Recent studies in mouse models have demonstrated that ketamine and rapastinel induce rapid-acting and sustained antidepressant effects in major depressive disorder (MDD). However, it remains unclear how ketamine's and rapastinel's opposing mechanisms of action-NMDAR antagonist and NMDAR positive allosteric modulator, respectively-result in similar antidepressant-like effects. Furthermore,...

DOI: 10.1007/s00221-025-07085-w Full text Ketamine Synaptic plasticity Bdnf Camkii/creb +7