Neuroplasticity: all studies (page 36) - The Consciousness Library

Acute Effects of the Psychedelic Phenethylamine 25I-NBOMe in C57BL/6J Male Mice.

International Journal of Molecular Sciences March 20, 2025 Sabrine Bilel, Cristina Miliano, Giorgia Corli et al. 3 citations

25I-NBOMe (4-Iodo-2,5-dimethoxy-N-(2-methoxybenzyl) phenethylamine) is a synthetic psychedelic compound abused for its ambiguous legal state as a counterfeit lysergic acid diethylamide (LSD). 25I-NBOMe acts as a selective agonist of 5HT2A receptors leading to hallucinations, intoxications, and fatalities. Here, we assessed the rewarding properties of 25I-NBOMe and its behavioral and neurotoxic...

DOI: 10.3390/ijms26062815 Full text Synaptic plasticity 25i-nbome 5ht2a agonist Ltd +8

The psychedelic psilocybin and light exposure have similar and synergistic effects on gene expression patterns in the visual cortex.

Molecular Brain March 18, 2025 Ram Harari, Dmitriy Getselter, Evan Elliott 2 citations

Psilocybin, a psychedelic compound found in specific hallucinogenic mushrooms, is known to induce changes in visual perception and experience in humans. However, there is little knowledge of the molecular mechanisms through which psilocybin affects vision-associated regions in the brain, such as the visual cortex. The current study determined both psilocybin-induced and experience-dependent...

DOI: 10.1186/s13041-025-01191-0 Full text Brain plasticity Visual perception Molecular biology Psychedelics

Mindfulness-Based Cognitive Therapy in Clinical Practice: A Systematic Review of Neurocognitive Outcomes and Applications for Mental Health and Well-Being.

Journal of Clinical Medicine March 3, 2025 Evgenia Gkintoni, Stephanos P. Vassilopoulos, Georgios Nikolaou 64 citations

Background/Objectives: This systematic review outlines the neurocognitive outcomes and mechanisms of mindfulness-based cognitive therapy (MBCT) that influence subjective well-being. MBCT is a clinical intervention that integrates cognitive therapy with mindfulness practices to prevent depression relapses and improve mental health. Methods: The review focuses on the effects of MBCT on brain...

DOI: 10.3390/jcm14051703 Full text Mindfulness Brain plasticity Mental health Cognitive therapy

Neural correlates of reduction in self-judgment after mindful self-compassion training: A pilot study with resting state fMRI.

Journal of Mood and Anxiety Disorders March 1, 2025 Diane Joss, Michael Datko, Charisma I. Washington et al. 5 citations

Self-judgment is a trans-diagnostic symptom among various psychological disorders, therefore can be a therapeutic target for many common psychiatric conditions. Self-judgment often arises among those who experienced childhood maltreatment, which increases the risk for developing comorbid psychiatric disorders that are resistant to traditional pharmacological and psychological interventions....

DOI: 10.1016/j.xjmad.2024.100096 Full text Mindfulness Neural plasticity Childhood trauma Compassion +2

Loving-Kindness Meditation: Systematic Review of Neuroimaging Correlates in Long-Term Practitioners and Clinical Implications.

Brain and Behavior March 1, 2025 Kiren Bashir, Stephen B. Edstrom, Sara J. Barlow et al. 4 citations

Introduction: Loving-kindness meditation (LKM), a meditation type focused on nurturing love and compassion for oneself and others, has been shown to provide mental health benefits, and LKM interventions are being investigated for mental disorders. The benefits of long-term practice, such as increased self-compassion, greater cognitive and affective empathy, and prosocial behavior, are proposed...

DOI: 10.1002/brb3.70372 Full text Neuroplasticity Loving-kindness meditation Lkm Compassion cultivation +14

[Mechanisms of action of antidepressive pharmacotherapy: brain and mind-body and environment].

Der Nervenarzt March 1, 2025 Moritz Spangemacher, Jonathan R Reinwald, Hana Adolphi et al.

Novel antidepressive substances are challenging the explanations for the mechanisms of action of traditional psychopharmacology. What could be the shared effects of various antidepressants and in this context what role do extrapharmacological factors, such as the body and environment, play? The available literature on clinical and preclinical data for assumed combined active factors of...

DOI: 10.1007/s00115-024-01786-3 Full text Brain plasticity Synaptic plasticity Extrapharmacological factors Antidepressants ssris +6

Ketamine-Assisted Psychotherapy for Generalized Anxiety Disorder: A Comprehensive Case Report with Integrated Neurophysiological Imaging Using Magnetoencephalography

medRxiv Preprint Server February 25, 2025 J Cohen, AC Reichelt, R Zamyadi et al. 1 citation preprint

This detailed case report explores the application of ketamine-assisted psychotherapy (KAP) in the treatment of a male patient in their late 30’s with Generalized Anxiety Disorder (GAD) and depressive symptoms. The N-methyl-D-aspartate (NMDA) receptor antagonist ketamine represents a significant breakthrough in the treatment of mood and anxiety disorders due to its rapid and robust...

DOI: 10.1101/2025.02.25.25322463 Full text Neuroplasticity Ketamine therapy Mental health

Muscarinic cannabinoid suppression of excitation, a novel form of coincidence detection.

Pharmacological Research February 1, 2025 Michaela Dvorakova, Ken Mackie, Alex Straiker 2 citations

Δ9-tetrahydrocannabinol (THC), the chief psychoactive ingredient of cannabis, acts in the brain primarily via cannabinoid CB1 receptors. These receptors are implicated in several forms of synaptic plasticity - depolarization-induced suppression of excitation (DSE), metabotropic suppression of excitation (MSE), long term depression (LTD) and activation-dependent desensitization. Cultured...

DOI: 10.1016/j.phrs.2025.107606 Full text Synaptic plasticity Autaptic hippocampal neurons Cb1 receptor M3/m5 muscarinic receptors

5-HT1B receptor activation produces rapid antidepressant-like effects in rodents.

Pharmacology, Biochemistry, and Behavior February 1, 2025 Erin A Clark, Lien Wang, Taleen Hanania et al. 5 citations

Ketamine is noted for its rapid onset antidepressant response and effectiveness in patients with treatment resistant depression. While most research has focused on glutamatergic mechanisms, recent studies show that antidepressant-like effects in rodents are dependent upon the serotonergic (5-HT) system and suggest a potential contribution of the 5-HT1B receptor. In this study we utilized...

DOI: 10.1016/j.pbb.2024.173917 Full text Synaptic plasticity 5-ht1b receptor agonist Lateral habenula circuit Rapid onset +5

Demystifying the Antidepressant Mechanism of Action of Stinels, a Novel Class of Neuroplastogens: Positive Allosteric Modulators of the NMDA Receptor.

Pharmaceuticals January 24, 2025 John E Donello, Roger S McIntyre, Donald B Pickel et al. 14 citations

Plastogens are a class of therapeutics that function by rapidly promoting changes in neuroplasticity. A notable example, ketamine, is receiving great attention due to its combined rapid and long-term antidepressant effects. Ketamine is an N-methyl-D-aspartate receptor (NMDAR) antagonist, and, in addition to its therapeutic activity, it is associated with psychotomimetic and dissociative side...

DOI: 10.3390/ph18020157 Full text Ketamine Synaptic plasticity N-methyl-d-aspartate receptor Mechanism +8