Shuwen Li

Ketamine rescues anhedonia by cell-type- and input-specific adaptations in the nucleus accumbens.

Neuron May 7, 2025 Federica Lucantonio, Jacob Roeglin, Shuwen Li et al. 24 citations

Ketamine is recognized as a rapid and sustained antidepressant, particularly for major depression unresponsive to conventional treatments. Anhedonia is a common symptom of depression for which ketamine is highly efficacious, but the underlying circuits and synaptic changes are not well understood. Here, we show that the nucleus accumbens (NAc) is essential for ketamine's effect in rescuing...