52 studies whose primary subject is mystical experience were published in 2025, up from 43 in 2024 and the most of any year since 2002.
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For more than four decades, the emphasis in the academic study of world religions has been on differences over similarities, and comparative analyses allowing for commonalities have become increasingly rare. This article argues that similarities nonetheless exist and should be studied. After disclaiming the judgment of other scholars that Aldous Huxley attempted to describe the “core” or...
ABSTRACT Self-transcendent experiences (STEs) represent profound shifts in cognition and consciousness, possessing significant transformative potential. With growing scientific interest in these phenomena, we propose the cognitive continuum as a unifying framework. Grounded in enactive cognitive science and complex dynamic systems perspectives, this approach takes the embodied person, embedded...
Abstract Mystical experiences are among the most extraordinary and meaningful experiences one can have. While such experiences have been studied for more than a century, it is still an open question how the brain can produce them. The present paper provides a possible answer by examining mystical experience from the lens of the REBUS hypothesis—a theory that explains the neurocognitive...
ReligionsDecember 4, 2025Anderson Fabián Santos Meza
In the twenty-first century, academic approaches to mysticism often risk reducing the Mystery to an object of erudition and historical distance, as if mystical experience belonged solely to a pre-modern past. Yet, when one encounters the “natural metaphors” that emerge within mystical writings—images of rivers, gardens, fire, and wind—it becomes almost impossible to silence the invitation to...
Atheists have long advanced arguments against the existence of God, challenging the claims of theists. Among these, John L. Schellenberg has proposed an argument known as “divine hiddenness,” which has garnered significant attention from philosophers of religion. Therefore, the subject of this paper is to critique and examine this argument based on the ontological foundations of Avicenna, one...
Ibogaine is an atypical psychedelic that evokes unique subjective effects, including mystical experiences. Mystical experiences have shown a mediating effect on clinical improvements following treatment with several psychedelic substances; however, the relationship between mystical experiences and clinical outcomes following ibogaine remains unclear. We examined the association between mystical...
Contemporary interpretations of psychedelic spirituality are dominated by the “mystical experience model,” which emphasizes that psychedelics can lead to well-being through bringing about ego dissolution and a unitive mystical experience. Rooted in perennialist and dualist assumptions—often derived from Christian mysticism, Vedanta, and Plotinian Neoplatonism—this framework has shaped both...
Mystical experiences are generally considered to be rare and special experiences, characterized by feelings of unity and self-loss. Still, certain researchers have recently proposed that mystical experiences could be placed on a continuum with more common and mundane experiences. In this paper, we present the results of an exploratory study, the goal of which was to identify ordinary...
5-Methoxy-N,N-dimethyltryptamine (5-MeO-DMT) is a naturally occurring psychedelic tryptamine. Plants containing 5-MeO-DMT have been used throughout history, and in recent years both synthetic and toad-derived 5-MeO-DMT use is being increasingly reported in naturalistic settings as well as clinical research. However, its subjective effects are not well characterised, and no qualitative research...
Abstract This paper argues that interactions with artificial intelligence (AI) chatbots, such as ChatGPT, can mediate genuine mystical experiences. Building off the framework of mystical experiences developed by William James, I argue that interactions with AI chatbots can mediate mystical experiences in a structurally comparable way to how guided meditation can produce mystical experiences. I...
In active inference, mystical experiences (MEs) could be characterized as adaptive learning events, where the ordinary expectations of an agent become challenged or change permanently. In the context of psychedelic-induced MEs, these (temporary) changes in information processing have been attributed to increased brain entropy, the effects of which have been seen to reorganize deep...
The paper critically discusses whether mystical experiences induced by psychedelics should be considered inauthentic or counterfeit forms of mystical experiences. It examines three arguments against the authenticity of these experiences: pimes are too easy; pimes do not have lasting spiritual or moral effects; pimes do not involve divine grace. Positive arguments for the authenticity of pimes...
Meditation and psychedelics have separately been studied as powerful tools for probing consciousness through their capacity to deconstruct the sense of self. Yet, direct empirical comparisons remain scarce, particularly in expert meditators. Here, we report for the first time a case study in which an advanced meditator and Lama from the Mahāmudrā meditation tradition engaged in a traditional...
Abstract Background Self-transcendent and mystical experiences may be key mechanisms underlying psychedelics’ therapeutic effects, yet how these experiences differ across substances remains unclear. This study compared mystical and self-transcendent experiences across psilocybin, 3,4-Methylenedioxymethamphetamine (MDMA), and cannabis in a diverse, community-based sample, while accounting for...
Abstract: Background: Delusions are common positive symptoms in schizophrenic patients. Individuals with delusional disorders have different experiences in memory and beliefs. Exploring patients’ delusional beliefs is crucial to ascertaining appropriate psychotherapy programs. A few studies have explored the meanings of delusions for delusional patients. This study explores how schizophrenic...
Along with the cultural interest in spirituality and mysticism in their various dimensions and meanings, which has been growing unabated for decades, there is a need for in-depth philosophical and theological reflection on the commonly referred to as mystical experience – an experiential dimension of religious life. In search of a theoretical elaboration of the phenomenon of human mystical...
This article examines one of the least studied aspects of the theological and philosophical thought of St. Gregory Palamas, viz. his doctrine of the Divine selfcontemplation. This teaching has previously been mentioned only briefl y and shortly by the following scholars: protopresbyter John Romanides, Reinhard Flogaus, Father Dr. Porphyrios (Fadi) Georgi, Mikhail Yuryevich Reutin. However, the...
<p><strong>Psilocybin, the psychoactive compound found in certain mushrooms, has gained increasing attention for its potential therapeutic applications in mental health treatment. While clinical research highlights its efficacy in alleviating mental disorders, such as depression, anxiety, PTSD, and substance use disorders, much remains to be known about the role of acute doses of psilocybin...
Relevance. As the psychopathology of religious experience developed in the second half of the 20th – early 21st century, a noticeable trend was the transition to a paradigm that orients psychiatric science toward a differentiated approach to religious-mystical experience. The change of paradigms requires the implementation of philosophical reflection through the prism of interdisciplinary...
Mystical experiences are powerful experiences that may have therapeutic value. Ketamine, a dissociative anesthetic, has shown potential to induce mystical experiences. However, little research has explored this phenomenon, particularly in treatment-resistant depression. We analyzed clinical data from 60 veterans with treatment-resistant depression receiving a total of 189 ketamine treatments....