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Neuropsychopharmacology August 1999 George K. Aghajanian, Gerard J. Marek
This brief review traces the serotonin (5-HT) hypothesis of the action of hallucinogenic drugs from the early 1950s to the present day. There is now converging evidence from biochemical, electrophysiological, and behavioral studies that the two major classes of psychedelic hallucinogens, the indoleamines (e.g., LSD) and the phenethylamines (e.g., mescaline), have a common site of action as...
Bulletin of the history of medicine September 1, 1998 Karen Reeds 3 citations
Reviewed by: Ethnobotany: Evolution of a Discipline Karen Reeds Richard Evans Schultes and Siri von Reis, eds. Ethnobotany: Evolution of a Discipline. Portland, Ore.: Timber Press, 1995. 414 pp. Ill. $49.95. As a word, ethnobotany is just a century old: it was coined by the American taxonomic botanist John W. Harshberger in 1895. As a discipline, it is barely a half-century old. Since 1941,...
Antiquity March 1, 1998 Anthony Sinclair
Had you been a young boy in the 1960s and wanted to try for yourself the psychedelic experience written about in books such as The doors of perception, how would you have acquired the necessary 'drugs'?f-'AIJL DEVEKE~JX wrote to Aldous Huxley and amazingly Huxley replied.Whilst Huxley could not supply, in this case mescaline, he wished him well in his quest, and by his 21sl birthday two small...
Pharmacology, Biochemistry, and Behavior February 1998 M D Schechter
A two-lever, food-motivated, operant technique was employed to train the purportedly serotonergically dysfunctional Fawn-Hooded (FH) rat to discriminate 1.5 mg/kg MDMA. Once all 10 male subjects learned the MDMA-vehicle discrimination at criterion performance level, doses different than the training dose were used to generate a dose-response discrimination gradient. The ED50 value of MDMA was...
Choice Reviews Online February 1, 1998 35 citations
Acknowledgements Introduction Part I. Religion and Reality: 1. Religion and philosophy 2. Where does the world come from? 3. The ontological argument and proof 4. Remarks on reality and religion 5. Natural theology 6. Religion and language 7. Belief in God 8. Wittgenstein on language and ritual 9. Religious practices 10. Notes on religion and reductionism 11. 'The divide' between religion and...
Endeavour 1998 S J Novak
Psychedelic drugs are making a comeback. Proponents of psychedelics point to the widespread medical experimentation with mescaline and lysergic acid diethylamide-125 (LSD) in the 1950s as proof of their safety and efficacy. However, a review of the private and published writings of Sidney Cohen, MD, who conducted the first study of the safety of psychedelics, reveals that serious medical...
Pharmacology, Biochemistry, and Behavior August 1997 L E Baker, M M Taylor
The phenylisopropylamine derivatives 3,4-methylenedioxymethamphetamine (MDMA) and 3,4-methylenedioxyamphetamine (MDA) have been compared to both psychostimulants and hallucinogens in drug discrimination investigations. The stereoisomers of these compounds, in particular those of MDA, appear to produce differential effects. Previous studies have demonstrated that animals trained to discriminate...
Biochemical Pharmacology June 1, 1997 D Wu, S V Otton, T Inaba et al.
The interaction of fifteen amphetamine analogs with the genetically polymorphic enzyme CYP2D6 was examined. All fourteen phenylisopropylamines tested were competitive inhibitors of CYP2D6 in human liver microsomes. The presence of a methylenedioxy group in the 3,4-positions of both amphetamine (Ki = 26.5 microM) and methamphetamine (Ki = 25 microM) increased the affinity for CYP2D6 to 1.8 and...
Journal of Neurochemistry December 1, 1996 R A Newton, S L Phipps, T P Flanigan et al. 46 citations
Stable transfection of the human neuroblastoma cell line SH-SY5Y with the human 5-hydroxytryptamine2A (5-HT2A) or 5-HT2C receptor cDNA produced cell lines demonstrating ligand affinities that correlated closely with those for the corresponding endogenous receptors in human frontal cortex and choroid plexus, respectively. Stimulation of the recombinant receptors by 5-HT induced phosphoinositide...
Journal of Pharmacology and Experimental Therapeutics February 1, 1996 R Young, Richard A Glennon
1-(3,4-Methylenedioxyphenyl)-2-aminopropane (MDA) produces an effect in humans that is somewhat similar to both a hallucinogen and a central stimulant. We have previously shown that R(-)-MDA but not S(+)-MDA produces a stimulus effect in animals similar to that of the hallucinogen 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM), whereas S(+)-MDA but not R(-)-MDA produces a stimulus effect...