Differential phospholipase C activation by phenylalkylamine serotonin 5‐HT2Areceptor agonists
Journal of Neurochemistry November 8, 2005 Jason C. Parrish, Michael R Braden, Emily Gundy et al. 40 citations
Experiments compared a series of phenethylamine hallucinogens with their phenylisopropylamine analogues for binding affinity and ability to stimulate serotonin 5-HT 2A receptor-mediated hydrolysis of phosphatidyl inositol in cells expressing cloned rat and human 5-HT 2A receptors. The (+/-)phenylisopropylamine analogues had significantly higher intrinsic activities for 5-HT 2A receptor-mediated...
DOI: 10.1111/j.1471-4159.2005.03477.x (opens in new tab)
Serotonin
Phenethylamine
5-HT Receptor
Stereochemistry
+2