Differential phospholipase C activation by phenylalkylamine serotonin 5‐HT2Areceptor agonists
Journal of Neurochemistry November 8, 2005 Jason C. Parrish, Michael R Braden, Emily Gundy et al. 40 citations
Experiments compared a series of phenethylamine hallucinogens with their phenylisopropylamine analogues for binding affinity and ability to stimulate serotonin 5-HT 2A receptor-mediated hydrolysis of phosphatidyl inositol in cells expressing cloned rat and human 5-HT 2A receptors. The (+/-)phenylisopropylamine analogues had significantly higher intrinsic activities for 5-HT 2A receptor-mediated...