The effects of mescaline upon single cortical neurones were studied, using the microiontophoretic technique. Mescaline elicited excitatory and depressant responses similar to those evoked by noradrenaline (NA) and 5-hydroxytryptamine (5-HI). The responses to NA and mescaline were usually in the same direction, the neurone being either excited by both drugs or depressed by both drugs. The...
1. The effect of spermidine on the mescaline-induced changes of brain-cortex ribosomes was studied by adding spermidine during the treatment of goat brain-cortex slices with mescaline. 2. Mescaline treatment of brain-cortex slices removed a portion of the endogenous spermidine from ribosomes and this removal was significantly prevented when spermidine was present during mescaline treatment. 3....
The fruiting bodies of C.laeve are several cm across, roundish, latercoalescing, soft and separable from the substrate.The colour is variable, brownish, light brownish-gray yellow to a gray brownwith a whitish, samewhat hairy margin.Upper surface smooth often cracked.Basidia 25-40-90 X 45.:_9 fl; spores obovate, sometimes slightly bent at the base 7-9-r2 X 45-7 fl (Bourd.and Galz.).In the...
EpilepsiaSeptember 1, 1970C Pintilie, N Mison-Crighel, E Crighel1 citation
SUMMARY The evolution of a spiking focus induced by topical application of mescaline, as well as the concomitant alterations in the free amino acids in the two ectosylvian and the two marginal areas, were studied in cats pretreated with nonconvulsant doses of pentetrazol or caffeine. The spiking focus appeared earlier than it did in noninjected animals; the spikes were very frequent and...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotocyclizations of pharmacodynamic amines. V. Unusual rearrangements of the mescaline skeletonOsamu Yonemitsu, Hideo Nakai, Yuichi Kanaoka, Isabella L. Karle, and Bernhard WitkopCite this: J. Am. Chem. Soc. 1970, 92, 19, 5691–5700Publication Date (Print):September 1, 1970Publication History Published online1 May 2002Published inissue 1 September...
1. The action of mescaline sulphate on the hydrogen-bonded structure of the RNA constituent of ribosomes of goat brain-cortex slices was studied by using the hyperchromic effect of heating and formaldehyde reaction. 2. The ribosomal total RNA species of the mescaline-treated brain-cortex slices have a smaller proportion of hydrogen-bonded structure than the ribosomal RNA species of the...
1. During the action of mescaline sulphate on goat brain-cortex slices the ribosomal particles become susceptible to breakdown, releasing protein, RNA, acidsoluble nucleotides and ninhydrin-positive materials, resulting in loss of ribosomal enzyme activities. 2. Ribosomes of the mescaline-treated cortex slices undergo rapid degradation in the presence of trypsin and ribonuclease. 3. Mescaline...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotocyclizations of pharmacodynamic amines. III. Three-dimensional structure of 7-hydroxy-1,9,10-trimethoxy-4-azabicyclo[5.2.2]undeca-8,10-dien-3-one from mescalineOsamu Yonemitsu, H. Nakai, Yuichi Kanaoka, Isabella L. Karle, and Bernhard WitkopCite this: J. Am. Chem. Soc. 1969, 91, 16, 4591–4593Publication Date (Print):July 1, 1969Publication...