This review covers essentially derivatives of phenethylamine and phenylisopropylamine which contain three phenolic hydroxyl groups and their alkyl ethers. They comprise mescaline, its amphetamine analog and their position isomers. The chemistry, biochemistry and pharmacology of these compounds are the subject of sections of this review.
Malformations of the brain, spinal cord, liver, and other viscera; body edema; and localized hemorrhages were found in fetal hamsters from mothers injected subcutaneously with a single dose of mescaline, lysergic acid diethylamide, or 2-bromo-D lysergic acid diethylamide on the 8th day of pregnancy. In addition, all three drugs produced an increase in the percentages of small fetuses per...
SUMMARY An cctosylvian spiking focus, induced by topical application of mescaline, brought about changes in nitrogenous compounds not only in the focus but throughout the cerebral cortex. Prior to the onset of the spiking focus, 2 min after mescaline application, ammonia levels increased significantly in all neocortical areas, especially at the focus and homolateral marginal gyrus; free amide...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBiosynthesis of the Peyote Alkaloids. The Incorporation of Tyrosine-2-C14 into Mescaline and Anhalonidine1Edward LeeteCite this: J. Am. Chem. Soc. 1966, 88, 18, 4218–4221Publication Date (Print):September 1, 1966Publication History Published online1 May 2002Published inissue 1 September...
Transections of the brain of rabbit reveal that electroencephalographic arousal produced by injections of adrenaline takes place at the midbrain level, while mescaline and 3,4-dimethoxyphenylethylamine induce such arousal lower in the brainstem, at the medullary level.
Human subjects given labeled β-(3,4 ,5-trimethoxyphyphenyl) -ethylanoine by mouth excrete an average of 81.9% of the administered dose in the urine during the first 12 hours. An average of 26.2% of the administered dose is excreted in the urine as free TMPA. TMPA given to humans by mouth produces no physiological or psychological changes.
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBridged Lactones and Bridged Carbocyclic Systems from 2-(3,4,5-Trimethoxyphenyl)-4,5-dimethyl-Δ4-cyclohexenecarboxylic Acid. Novel Mescaline Analogs1Thomas J. Perun, Leo Zeftel, Robert G. Nelb, and D. Stanley TarbellCite this: J. Org. Chem. 1963, 28, 11, 2937–2943Publication Date (Print):November 1, 1963Publication History Published online1 May...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of Phenethylamines Related to Mescaline as Possible Psychotomimetic Agents1Orrie M. Friedman, K. N. Parameswaran, and Sumner BursteinCite this: J. Med. Chem. 1963, 6, 3, 227–229Publication Date (Print):May 1, 1963Publication History Published online1 May 2002Published inissue 1 May...