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Venoms and Toxins September 15, 2023 Nor Suliana Mustafa, Mohd Nazri Mohd Daud, Nasir Mohamad et al.
Keywords: 3, 4 methylenedioxymethamphetamine, MDMA, microglia, neurotoxicity syndrome, inflammation, phenotype.
Molecular Biology Reports September 9, 2023 Xin Geng, Shipeng Li, Jinghui Li et al. 3 citations
BACKGROUND: Parkinson's disease (PD) is a well-known neurodegenerative disease that is usually caused by the progressive loss of dopamine neurons and the formation of Lewy vesicles. 3,4-Methylenedioxymethamphetamine (MDMA) has been reported to cause damage to human substantia nigra neurons and an increased risk of PD, but the exact molecular mechanisms need further investigation. METHODS: MPTP-...
Addiction and Health September 4, 2023 Iman Rad, Arezoo Saberi, Najmeh Sadat Koochakzadeh-Nematollahi et al. 6 citations
Background: There is an increasing concern over acute exposure of amphetamine and its derivative such as3,4-methylenedioxymethamphetamine (MDMA) on male reproductive toxicity. Supplementary vitamins canreduce the oxidative stresses and repair the damages on reproductive organs. This experimental study wasconducted to evaluate the effects of folic acid (FA) on reproductive indices, the...
Biological Psychiatry: Cognitive Neuroscience and Neuroimaging September 2023 Rebecca C Coray, Jatta Berberat, Josua Zimmermann et al.
The common club drug MDMA (also known as ecstasy) enhances mood, sensory perception, energy, sociability, and euphoria. While MDMA has been shown to produce neurotoxicity in animal models, research on its potential neurotoxic effects in humans is inconclusive and has focused primarily on the serotonin system. We investigated 34 regular, largely pure MDMA users for signs of premature...
September 1, 2023 Aldo Chiquini
La microdosificación (o las microdosis) hace referencia al ingerir una dosis muy baja de una sustancia psicodélica, donde no hay efectos de alteraciones cognitivas, afectivas, perceptivas y neurofisiológicas. Recientemente instituciones como la MAPS, la Universidad Johns Hopkins, el Imperial College of London y la FDA, a dicha microdosificación le han designado como «terapia innovadora», ya que...
Psychedelic Medicine September 1, 2023 Harpreet Kaur, Sedat Karabulut, James W Gauld et al. 10 citations
Autism spectrum disorder (ASD) encompasses a range of neurodevelopmental syndromes diagnostically characterized by deficits in social communication and social interaction and repetitive, inflexible patterns of behaviors, interests, and thoughts. ASD affects people worldwide, irrespective of race, ethnicity, or socio-economic status, with debilitating effects on employment and interpersonal...
Scientific Reports August 22, 2023 Hannes Kettner, Stephen Ross, Richard J. Zeifman et al. 31 citations
Abstract Psilocybin and lysergic acid diethylamide (LSD) experiences can range from very positive to highly challenging (e.g., fear, grief, and paranoia). These challenging experiences contribute to hesitancy toward psychedelic-assisted psychotherapy among health care providers and patients. Co-use of 3,4-Methylenedioxy methamphetamine (MDMA) with psilocybin/LSD anecdotally reduces challenging...
Scholarworks (University of Massachusetts Amherst) August 15, 2023 Christina S. Henderson
We previously found that intermittent administration of 3,4-methylenedioxymethamphetamine (MDMA, “Ecstasy”) to adolescent male rats protected against the behavioral and serotonergic neurotoxic effects of a subsequent MDMA binge. Similar results have been reported for the dopamine (DA) neurotoxin methamphetamine (METH). The present study tested the hypothesis that intermittent adolescent MDMA...
Journal of Education, Health and Sport August 15, 2023 Karol Womperski, Rafał Bogacz, Magdalena Gaik et al. 1 citation
Introduction: Post-traumatic stress disorder (PTSD) is a common health issue of complex etiology significantly deteriorating functioning in everyday life. It may develop as a result of exposure to traumatic events like traffic accidents, war experience, sexual abuse and domestic violence. Current methods of treatment consist of trauma-oriented psychotherapy supported by selective serotonin...
Journal of Psychopharmacology August 12, 2023 Michael Tagen, Daniel Mantuani, Alex Holstein et al. 39 citations
Psychedelic microdosing is the practice of taking very low doses of psychedelic substances, typically over a longer period of time. The long-term safety of chronic microdosing is relatively uncharacterized, but valvular heart disease (VHD) has been proposed as a potential risk due to activation of the serotonin 5-HT 2B receptor. However, this risk has not yet been comprehensively assessed. This...