Journal of Psychopharmacology
February 21, 2017
Patrick Vizeli, Matthias E. Liechti
142 citations
3,4-Methylenedioxymethamphetamine (MDMA; ecstasy) is being investigated in MDMA-assisted psychotherapy. The present study characterized the safety pharmacology of single-dose administrations of MDMA (75 or 125 mg) using data from nine double-blind, placebo-controlled, crossover studies performed in the same laboratory in a total of 166 healthy subjects. The duration of the subjective effects...
Neurotoxicology and Teratology
February 16, 2017
N. Miner, J. O'Callaghan, T. Phillips et al.
25 citations
The rise in popularity of substituted methcathinones (aka “bath salts”) has increased the focus on their neurotoxic effects. Two commonly abused methcathinones, 3,4-methylenedioxymethcathinone (methylone, MDMC) and 3,4-methylenedioxypyrovalerone (MDPV), are often concomitantly ingested with the illicit drug 3,4-methylenedioxymethamphetamine (MDMA). To examine potential neurotoxic effects of...
Behavioural Brain Research
February 15, 2017
María P García-Pardo, Concepción Roger-Sánchez, Marta Rodríguez‐arias et al.
Adverse life experiences such as social stress may make an individual more vulnerable to drug addiction and mental disorders associated with drug consumption. The present work aimed to evaluate the effects of stress induced by acute social defeat combined with the administration of 3,4-methylenedioxymethamphetamine (MDMA) on depression-like behaviour, memory function and motor response to drug...
Neuropsychopharmacology
February 14, 2017
Ishan C Walpola, Timothy Nest, Leor Roseman et al.
50 citations
Recent work with noninvasive human brain imaging has started to investigate the effects of 3,4-methylenedioxymethamphetamine (MDMA) on large-scale patterns of brain activity. MDMA, a potent monoamine-releaser with particularly pronounced serotonin- releasing properties, has unique subjective effects that include: marked positive mood, pleasant/unusual bodily sensations and pro-social, empathic...
Psychopharmacology
February 10, 2017
Ross Van de Wetering, Susan Schenk
Rationale: Repeated exposure to ±3, 4-methylenedioxymethamphetamine (MDMA) produces sensitization to MDMA-produced hyperactivity, but the mechanisms underlying the development of this sensitized response or the relationship to the reinforcing effects of MDMA is unknown. Objectives: This study determined the effect of a sensitizing regimen of MDMA exposure on the acquisition of MDMA...
Drug Metabolism and Personalized Therapy
January 26, 2017
Bardia Jamali, Behjat Sheikholeslami, Yalda Hosseinzadeh Ardakani et al.
6 citations
AbstractBackground:Tramadol is prone to be abused alone, or in combination with 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy). It was reported that 95% of people with a history of substance abuse in the United States used tramadol in 2004. According to the WHO report in 2016, there was a growing number of tramadol abusers alone or in combination with psychoactive substances such as MDMA in...
Journal of Chemistry
2017
Wan Raihana Wan Aasim, Soo Choon Tan, Siew Hua Gan
Abuse of 3,4-methylenedioxymethamphetamine (MDMA) is becoming more common worldwide. To date, there is no information available on stereoselectivity of MDMA protein binding in humans, rats, and mice. Since stereoselectivity plays an important role in MDMA’s pharmacokinetics and pharmacodynamics, in this study we investigated its stereoselectivity in protein binding. The stereoselective protein...
Research Open
2017
Katie Anderson
MDMA (3,4-methylenedioxy-methamphetamine or ‘ecstasy’) is well-known for its empathic and sociable effects (Bogt, Engels, Hibbel & Van Wel, 2002). Indeed, there is a body of work that discusses the role the drug plays in social bonding (Beck & Rosenbaum, 1998; Duff, 2008; Farrugia, 2015; Hinchliff, 2001; Solowij, Hall & Lee, 1992). However, there has been extremely limited research looking at...
2017
F. H. Zakaria, Norhafidah Abu, Nasir Mohamad
he trend of drug use has changed tremendously in this millennium (Adnan et al., 2014). Over the past decade, opioids are among the primary drug of abuse in worldwide. However the trend towards using amphetamine-type stimulant (ATS) is notably increasing lately. Amphetamine-type stimulants are a group of drugs consisting mainly of amphetamine and metamphetamine; these include methcathinone,...
Substance Abuse
2017
Joseph J Palamar
Molly has been the street name for powder or crystalline ecstasy (3,4-methylenedioxymethamphetamine [MDMA]) in the United States since the early 2000s; however, few studies have examined Molly use or included Molly in the definition of ecstasy/MDMA. Prevalence of self-reported ecstasy use is being underreported on surveys due to the lack of inclusion of "Molly," although Molly is often so...