Abstract With novel hallucinogens poised to enter psychiatry, we lack a unified framework for quantifying which changes in consciousness are optimal for treatment. Using transformers (i.e. BERT) and 11,816 publicly-available drug testimonials, we first predicted 28-dimensions of sentiment across each narrative, validated with psychiatrist annotations. Secondly, BERT was trained to predict...
New medicines containing classic hallucinogenic and entactogenic psychedelic substance are under development for various psychiatric and neurological disorders. Many of these, including psilocybin, lysergic acid diethylamide (LSD), and 3,4-methylenedioxymethamphetamine (MDMA) are Schedule I controlled substances of the United States Controlled Substances Act (US CSA), and similarly controlled...
There is mounting evidence suggesting psychedelic and entactogen medicines (namely psilocybin and 3,4-methylenedioxymethamphetamine [MDMA]), in conjunction with proper psychosocial support, hold the potential to provide safe, rapid acting, and robust clinical improvements with durable effects. In the US, both psilocybin and MDMA have been granted Breakthrough Therapy designations by the US Food...
Festival drug-related deaths are a growing public health concern. To examine drug use and related harm-reduction practices and attitudes towards utilisation of drug safety testing services. Data collection took place over the 2019 festival season (June-October). The questionnaire was self-reported. Data was gathered via the online survey, which was promoted through online and social media...
The mode of 'comparison' is essential, especially when it comes to the contemplation of Marguerite Porete and Hadewijch, the French and Dutch Beguine mystics from 13th century; Their notoriously enigmatic mysticism, by which radical and unique meditations on indistinct union with Divine are expressed in erotic and ecstatic manner, may discover a counterpart in nondualist tantric traditions of...
Botanical Ecstasies: Psychoactive Plant Formulas in India and Beyond, by Matthew Clark. London: Psychedelic Press, 2021. 69 pp. £9.99 (pb). ISBN 978191626711.
Abstract To understand how pharmacological interventions can exert their powerful effects on brain function, we need to understand how they engage the brain’s rich neurotransmitter landscape. Here, we bridge microscale molecular chemoarchitecture and pharmacologically-induced macroscale functional reorganisation, by relating the regional distribution of 19 neurotransmitter receptors and...
Метою дослідження є характеристика методу РАТ (Psychedeilc Assisted Therapy) та окреслення перспектив його впровадження в Україні. Методологія та методи. Використано методи теоретичного аналізування наукової літератури. Результати. З’ясовано, що за попередніми оцінками, щонайменше 23.5 млн. українських громадян ризикують зустрітися з погіршенням психічного здоров’я: до 20.0% з них – середнього...
Mid-20th-century American research on psychedelics evinced a stunning diversity of interpretations of hallucinogenic effects. While some researchers viewed psychedelics as invaluable tools for psychotherapy, others persisted in treating them as psychosis-inducing agents. As some groups considered psychedelics as catalysts for artistic creativity, others investigated their potential use as...
Abstract This is a narrative review about the role of classic and two atypical psychedelics in the treatment of unipolar and bipolar depression. Since the 1990s, psychedelics experience a renaissance in biomedical research. The so-called classic psychedelics include lysergic acid diethylamide (LSD), psilocybin, mescaline and ayahuasca. Characteristic effects like alterations in sensory...