Journal of Studies on Alcohol and Drugs
March 22, 2024
David Nutt, Celia J. A. Morgan, Sukhpreet Klaire
This Perspectives piece gives a brief overview on the last 70 years of psychedelic research in relation to the treatment of mental illness with a particular focus on addictions. We briefly precis the work in the 19650s/60s that started following the discovery of LSD. Then we overview research developments over the past twenty years driven by emerging neuroscience on these agents, the rise of...
Wiley Interdisciplinary Reviews Forensic Science
March 19, 2024
Julio Ponce
6 citations
Abstract Prodrugs are an important strategy for the development and design of therapeutic drugs. They involve the addition of an easily removable group (such as an ester) to a molecule in order to chemically protect it from metabolism, hydrolysis, or interaction with tissues. In the therapeutic drug market, prodrugs may reduce adverse effects, lead to more accurate tissue delivery, increase...
The Biochemist
March 14, 2024
Natalie Ertl, Matthew B. Wall
The use of psychoactive substances for ritual, spiritual and medicinal purposes stretches back into prehistory and has been a common feature of many diverse cultures and societies globally. Psychedelics, with their unique ability to amplify feelings of connectedness and openness, may have also served as tools for promoting tribal cohesion and trust in ancient cultures. Psychedelic is a broad...
Knowable Magazine
March 14, 2024
Ben Seal
1 citation
When Oregon's first psilocybin service center opened in June 2023, allowing those over 21 to take mind-altering mushrooms in a state-licensed facility, the psychedelic revival that had been unfolding over the past two decades entered an important new phase. Psilocybin is still illegal on the federal level. But now, as researchers explore the therapeutic potential of psilocybin and other...
March 13, 2024
Susan Blackmore, Emily T. Troscianko
46 citations
Altered states of consciousness (ASCs) are surprisingly hard to define and to measure. Neither ‘subjective’ methods (like verbal reports) nor ‘objective’ measures (such as how the state is induced, or physiological and behavioural criteria) are entirely satisfactory. Attempts to map ASCs are reviewed, including two- or three-dimensional maps such as Tart&s;s and Laureys’, and Hobson&s;s AIM...
March 6, 2024
Bill Brennan, Alex Belser
6 citations
Abstract EMBARK Psychedelic Therapy for Depression: A New Approach for the Whole Person is a comprehensive guidebook for clinicians that presents a novel therapeutic framework for administering psychedelic medicines. The EMBARK model was developed in response to the growing interest in psychedelic medicines for treating mental health disorders, particularly depression, and the identified gaps...
Drug and Alcohol Review
March 4, 2024
Monica J Barratt, Matthew Ball, Gabriel T. W. Wong et al.
18 citations
INTRODUCTION: Prohibited drugs in unregulated markets may be adulterated, resulting in increased risks for people who use drugs. This study investigated levels of drug adulteration and substitution of drugs purchased in Australia from cryptomarkets. METHODS: Data were collected from a darknet forum called Test4Pay from 1 September 2022 to 23 August 2023. Posts were included if they reported the...
Psychedelic Medicine
March 1, 2024
Justin C Strickland, Albert Garcia‐romeu, Matthew W Johnson
20 citations
The Mystical Experience Questionnaire (MEQ-30) and Challenging Effects Questionnaire (CEQ) are two of the most widely used, validated instruments to probe subjective effects of psychedelic drugs. However, these assessments are lengthy and can be a burden to study participants or patients if administered during acute psychedelic effects, after resolution of psychedelic effects when participants...
Journal of Education, Health and Sport
February 22, 2024
Krzysztof Marcinkowski, Agata Mazur, Magdalena Madera et al.
Introduction and purpose: Post-traumatic stress disorder is a psychiatric condition following an extreme event that causes a near death of an involved individual. Since conventional treatments using selective serotonin reuptake inhibitors do not consistently yield therapeutic success, alternative substances are being explored as potential solutions. This study aims to compile information...
Neural Regeneration Research
February 22, 2024
Marcello Serra, Nicola Simola, Alexia E Pollack et al.
19 citations
Preclinical and clinical studies indicate that psychostimulants, in addition to having abuse potential, may elicit brain dysfunctions and/or neurotoxic effects. Central toxicity induced by psychostimulants may pose serious health risks since the recreational use of these substances is on the rise among young people and adults. The present review provides an overview of recent research,...