Behavioural Pharmacology
March 1, 2004
William E Fantegrossi, James H Woods, Gail Winger
99 citations
Relatively few studies have assessed the reinforcing effects of hallucinogenic compounds, and no such studies have attempted to engender contingent responding for these compounds in animals with behavioral histories that include experience with serotonergically mediated reinforcing effects. The objectives of the present study were to investigate the capacity of several hallucinogenic compounds...
British and Irish Orthoptic Journal
2004
Alison Firth
13 citations
Aim: To highlight the changes that may take place in the visual system of the class A drug abuser.Methods: A literature review was carried out of ocular/visual sequelae of the more common class A drugs. These include stimulants (cocaine and crack cocaine), narcotics (heroin, morphine, methadone) and hallucinogenics (ecstasy, lysergic acid diethylamide, magic mushrooms, mescaline,...
Emergency Medicine News
December 1, 2003
Leon Gussow
A 25-year-old man was brought to the emergency department from a late-night dance club. A friend reported that the patient commonly used designer drugs that he purchased over the Internet. While at the club, he started to vomit and experience visual hallucinations. He had no previous medical history and took no prescription medications. On searching the patient's clothing, medical staff found...
The British Journal of Criminology
October 1, 2003
M. Shiner
14 citations
Although British drugs policy has become increasingly contested, debate in this area has continued along well-established lines. Recent reviews, including those conducted by the independent inquiry into the Misuse of Drugs Act and the Select Committee on Home Affairs, have called for reform largely on the basis of the established medicalized philosophy. While the related notions of...
Therapeutic Drug Monitoring
April 1, 2002
Thomas Kræmer, Hans H Maurer
232 citations
This paper reviews the toxicokinetics of amphetamines. The designer drugs MDA (methylenedioxy-amphetamine, R,S-1-(3;,4;-methylenedioxyphenyl)2-propanamine), MDMA (R,S-methylenedioxymethamphetamine), and MDE (R,S-methylenedioxyethylamphetamine), as well as BDB (benzodioxolylbutanamine; R,S-1-(1;,3;-benzodioxol-5;-yl)-2-butanamine or R,S-1-(3;,4;-methylenedioxyphenyl)-2-butanamine) and MBDB...
Therapeutic Drug Monitoring
April 1, 2002
Manfred R. Moeller, Thomas Kræmer
98 citations
Driving under the influence of drugs is an issue of growing concern in the industrialized countries as a risk and a cause for road accidents. In forensic toxicology, the increasing number of samples for determination of drugs in blood is mainly due to zero-tolerance laws in several countries and well-trained police officers who can better recognize drivers under the influence of drugs of abuse....
Dialogues in Clinical Neuroscience
December 31, 2001
Franz X. Vollenweider
127 citations
This review focuses on recent brain imaging and behavioral studies of sensory gating functions, which assess similarities between the effects of classic hallucinogens (eg, psilocybin), dissociative anesthetics (eg, ketamine), and entactogens (eg, 3,4-methylenedioxymethamphetamine [MDMA]) in humans. Serotonergic hallucinogens and psychotomimetic anesthetics produce overlapping psychotic...
Pharmacogenetics
August 1, 2001
Yamini Ramamoorthy, Rachel F. Tyndale, Edward M. Sellers
92 citations
CYP2D6 is involved in the metabolism of several classes of drugs, including tricyclic antidepressants, selective serotonin reuptake inhibitors and various amphetamines. CYP2D6*10 is an allelic variant, producing an enzyme with Pro34Ser and Ser486Thr amino acid substitutions. Approximately 75% of Asians possess the *10 allele. We sought to further characterize CYP2D6.10 catalytically in vitro in...
Addiction
July 1, 2001
Sarah Riley, Charlotte James, Danielle Gregory et al.
172 citations
Aims . To describe the patterns of drug use at dance (rave) events in terms of prevalence, frequency, type of drugs used, patterns of use, access and risk‐associated behaviours. Design . Self‐selecting participant‐completed survey. Setting . Three dance events in Edinburgh, Scotland, UK. Participants . One hundred and twenty‐two drug users (57% males, 43% females), 90% of whom were in...
Synapse
2000
Richard B Rothman, Michael H. Baumann, Christina M Dersch et al.
933 citations
A large body of evidence supports the hypothesis that mesolimbic dopamine (DA) mediates, in animal models, the reinforcing effects of central nervous system stimulants such as cocaine and amphetamine. The role DA plays in mediating amphetamine-type subjective effects of stimulants in humans remains to be established. Both amphetamine and cocaine increase norepinephrine (NE) via stimulation of...