Current Pharmaceutical Biotechnology
2025
Maram B Alhawarri, Suleiman Olimat
10 citations
Silene undulata is historically used for inducing vivid and prophetic lucid dreams, but limited information exists on its phytochemical composition and potential pharmacological properties. This study aimed to investigate the phytochemical composition of S. undulata through LC-MS/MS analysis and explore its potential serotonergic activity, which could support and confirm the traditional use of...
Current Pharmaceutical Biotechnology
June 21, 2018
Moritz Haaf, Gregor Leicht, Stjepan Curic et al.
53 citations
BACKGROUND: The observation that N-methyl-D-aspartate glutamate receptor (NMDAR) antagonists such as ketamine transiently induce schizophrenia-like positive, negative and cognitive symptoms has led to a paradigm shift from dopaminergic to glutamatergic dysfunction in pharmacological models of schizophrenia. NMDAR hypofunction can explain many schizophrenia symptoms directly due to...
Current Pharmaceutical Biotechnology
August 2010
Margherita Neri, Stefania Bello, Alessandro Bonsignore et al.
Indirect effects of 3,4-methylenedioxy-N-methylamphetamine (MDMA) and metabolites on the cardiac cells are well-known, the mechanism(s) underlying direct MDMA-induced cardiotoxicity remaining to be clarified. To better understand the immuno-inflammatory phenomena accompanying the cardiac alterations during MDMA administration, we conducted a study in an in vivo animal model to evaluate the...
Current Pharmaceutical Biotechnology
August 2010
Sylvia K Shenouda, F Carvalho, Kurt J Varner
The recreational use of 3, 4 methylenedioxymethamphetamine (ecstasy or MDMA) has increased dramatically over the past thirty years due to its ability to increase stamina and produce feelings of emotional closeness and wellbeing. In spite of the popular perception that MDMA is a safe drug, there is a large literature documenting that the drug can produce significant neurotoxicity, especially in...
Current Pharmaceutical Biotechnology
August 1, 2010
Causes and effects of cellular oxidative stress as a result of MDMA abuse.
Current Pharmaceutical Biotechnology
August 1, 2010
MDMA administration and heat shock proteins response: foreseeing a molecular link.
Current Pharmaceutical Biotechnology
August 1, 2010
Márcia Carvalho, Helena Pontes, Fernando Remião et al.
3,4-Methylenedioxymethamphetamine (MDMA or ecstasy) is a worldwide illegally used amphetamine-derived designer drug known to be hepatotoxic to humans. Jaundice, hepatomegaly, centrilobular necrosis, hepatitis and fibrosis represent some of the adverse effects caused by MDMA in the liver. Although there is irrefutable evidence of MDMA-induced hepatocellular damage, the mechanisms responsible for...
Current Pharmaceutical Biotechnology
August 1, 2010
Mice in ecstasy: advanced animal models in the study of MDMA.
Current Pharmaceutical Biotechnology
June 27, 2010
Byoung‐joon Song, Kwan–hoon Moon, Vijay Upreti et al.
73 citations
Despite numerous reports about the acute and sub-chronic toxicities caused by MDMA (3,4-methylenedioxymethamphetamine, ecstasy), the underlying mechanism of organ damage is poorly understood. The aim of this review is to present an update of the mechanistic studies on MDMA-mediated organ damage partly caused by increased oxidative/nitrosative stress. Because of the extensive reviews on...
Current Pharmaceutical Biotechnology
June 27, 2010
Sumit Sarkar, Larry Schmued
63 citations
"Ecstasy" (MDMA) is a powerful hallucinogenic drug which has raised concern worldwide because of its high abuse liability. A plethora of studies have demonstrated that MDMA has the potential to induce neurotoxicity both in human and laboratory animals. Although research on MDMA has been carried out by many different laboratories, the mechanism underlying MDMA induced toxicity has not been fully...
Current Pharmaceutical Biotechnology
June 27, 2010
Emanuela Turillazzi, Irene Riezzo, Margherita Neri et al.
43 citations
Studies conducted in humans or in animals explored the presence, nature and potential causes of 3,4-methylenedioxymethamphetamine (MDMA) toxicity. According to literature, there are four principal types of such serious toxicity: hepatic, cardiovascular, cerebral and hyperpyrexic. The molecular mechanisms involved in the genesis of these toxic effects are not yet fully clarified, but the...