Psychiatric News
October 1, 2010
Aaron R. Levin
Ecstasy might take some of the agony out of psychotherapy for posttraumatic stress disorder (PTSD), if findings from a phase 2 pilot study are any indication. Outcomes of the small, randomized, double-blind, placebo-controlled trial indicated that MDMA, better known by its street name of ecstasy, may be useful as an adjunct to psychotherapy for patients with chronic, treatment-resistant PTSD....
Behavioral Neuroscience
October 1, 2010
David Quinteros-Muñoz, Patricio Sáez-briones, Gabriela Díaz-véliz et al.
12 citations
3,4-methylenedioxymethamphetamine (MDMA; "ecstasy") is a psychoactive drug structurally related to other phenylisopropylamines acting as stimulants or hallucinogens in humans. Although MDMA has a pharmacological identity of its own, the distinction of its acute effects from those of stimulants or even hallucinogens is controversial. In this work, dose-response curves (0.25, 0.5, 1, 3, 5, and 10...
Addiction Biology
October 1, 2010
Vicente Hernández‐rabaza, Graciela Navarro‐mora, Clara Velázquez-sánchez et al.
40 citations
ABSTRACT Recent trend assessments of drug consumption reveal an increase in the simultaneous use of several drugs at raves, clubs and college settings among youngsters and young adults. We studied in adolescent rats the effects of repeated exposure to cocaine and 3,4‐methylenedioxymethanphetamine (MDMA, ecstasy), given alone or in combination with alcohol, on memory performance, adult...
Brain Research
September 26, 2010
Acute MDMA administration alters the distribution and circadian rhythm of wheel running activity in the rat.
Neuroscience
September 25, 2010
Electrophysiological and structural alterations in striatum associated with behavioral sensitization to (±)3,4-methylenedioxymethamphetamine (Ecstasy) in rats: role of drug context.
Journal of Psychopharmacology
September 8, 2010
Tibor M Brunt, Anneke Poortman, Raymond J.m. Niesink et al.
217 citations
Recently, several reports have indicated instability of the ecstasy market in the Netherlands and other EU countries. In the current study, we demonstrate this instability in the Netherlands, showing a decrease of ecstasy tablets containing 3,4-methylenedioxymetamphetamine (MDMA) by more than 50% in 2009. In addition, we describe a partial replacement of MDMA in tablets sold as ecstasy by a...
Journal of Psychopharmacology
September 3, 2010
Gjh Dumont, J. G. Coen van Hasselt, M. de Kam et al.
38 citations
In Western societies a considerable percentage of young people expose themselves to the combination of 3,4-methylenedioxymethamphetamine (MDMA or ‘ecstasy’) and cannabis. The aim of the present study was to assess the acute effects of co-administration of MDMA and THC (the main psychoactive compound of cannabis) on pharmacokinetics, psychomotor performance, memory and subjective experience over...
Current Drug Abuse Reviews
September 1, 2010
Marinus N. Verbaten
10 citations
A quantitative meta-analysis was carried out on the chronic effects of ecstasy use on working memory (WM), assumed to consist of a central executive (CE) and four executive subcomponents: Updating, Attention shifting, Inhibition and Access to long term memory. Publications dating from January 1998 to January 2008 were only included when they fulfilled the criteria for a meta-analysis (number of...
Journal of Psychopharmacology
September 2010
Matthijs G. Bossong, Tibor M Brunt, J P Van Dijk et al.
A new ecstasy-like substance, meta-chlorophenylpiperazine (mCPP), has been detected in street drugs in the Netherlands. Theoretically, mCPP possesses the potential to become a non-neurotoxic alternative for methylenedioxymethamphetamine (MDMA), the regular psychoactive substance of ecstasy. Since its introduction on the Dutch market of synthetic drugs, the percentage of mCPP-containing tablets...
Revista clinica espanola
September 2010
Miguel Galicia, Santiago Nogué, E Sanjurjo et al.
To describe clinical and epidemiologic characteristics of emergency department visits related with ecstasy usage, determine the rate of re-visits of the patients and their related factors. The clinical histories of the patients coming to the Emergency Department for ecstasy-related problems were reviewed during 89 consecutive months in order to define the epidemiological and clinical profile....