The Open Addiction Journal
March 29, 2011
Esther Remmelink
Acute MDMA, even at low doses, increases social interaction in adult rats [1] while on the long-term its consumption produces a decrease in social interaction, an increase in anxiety and impaired object recognition memory [2, 3]. This study investigated whether MDMA has the same effects in adolescent rats. Additionally, we investigated whether the preference of adolescent rats for MDMA was...
The Open Addiction Journal
March 29, 2011
Allison J Matthews
1 citation
Remembering to do things in the future (prospective memory) and remembering things in our past (retrospective memory) are important everyday memory skills. Several studies suggest an association between use of ecstasy (3,4-methylenedioxymethamphetamine) and impairments in prospective (remembering to remember) and retrospective memory (recollection of past events) [1, 2]. However, some research...
The Open Addiction Journal
March 29, 2011
Jacqui Rodgers
7 citations
The aim of this investigation was to extend our previous work and establish whether the findings reported previously of self reports of memory difficulties associated with ecstasy use can be replicated. A web-based methodology was adopted due to the significant advantages such techniques may confer when trying to reach a specialized population or address questions that people might be reluctant...
The Open Addiction Journal
March 29, 2011
Amy K. O’Sullivan
1 citation
68 recreational Ecstasy/MDMA users were categorized into four subgroups: light versus heavy users (+20 occasions lifetime), subdivided into current and former users (usage within 6 months). Each unpaid volunteer completed a questionnaire about their personal experiences on Ecstasy/MDMA. The four questions here covered experiences the first and last times on Ecstasy. Positive effects were...
The Open Addiction Journal
March 29, 2011
David N. Harper
5 citations
disruption to working memory function [1, 2]. This possibility was examined using a version of the 8-arm radial maze task with rats that is designed to separate working memory function from reference memory function [3]. In Experiment 1 the effects of MDMA were compared to the classic amnetic drug scopolamine (which has been shown to produce working memory deficits in the current radial arm...
The Open Addiction Journal
March 29, 2011
John Brown
1 citation
A growing body of evidence suggests that regular ‘ecstasy’ (3, 4-methylenedioxymethamphetamine; MDMA) use causes lasting changes to central serotonergic functioning in humans, including in the occipital lobe. Brown, Edwards, et al. [1] proposed that MDMA-related serotonergic changes in the occipital lobe may reduce lateral inhibition between occipital neurons involved in low level visual...
The Open Addiction Journal
March 29, 2011
David N. Harper
4 citations
This study used the Drug Discrimination paradigm to assess the relative subjective experience of acutely administered 3,4-Methylenedioxymethamphetamine (MDMA) and d-amphetamine (AMPH). In this paradigm rats are required to respond on one lever if they have been given a specific drug (AMPH for one group of rats or MDMA for another group) vs an alternate lever if they have been administered...
The Open Addiction Journal
March 29, 2011
Vanessa Gwendoline Smithies
4 citations
3,4-Methylenedioxymethamphetamine (MDMA; ‘Ecstasy’) shares psychoactive effects with drugs that possess stimulant (e.g. amphetamine, the effects of which are primarily dopaminergic) and hallucinogenic properties (e.g. LSD, which has serotonergic effects) [1]. The majority of MDMA’s distinctive effects as well as its toxicity have been linked to its actions on serotonergic neurotransmission [2]....
Journal of Neurology, Neurosurgery, and Psychiatry
March 28, 2011
Bjørnar den Hollander, M.L.J. Schouw, P.F.C. Groot et al.
27 citations
Various studies have shown that ecstasy (3,4-methylenedioxymethamphetamine) users display significant memory impairments, whereas their performance on other cognitive tests is generally normal. The hippocampus plays an essential role in short-term memory. There are, however, no structural human data on the effects of ecstasy on the hippocampus. The objective of this study was to investigate...
Toxicology Letters
March 22, 2011
3,4-methylenedioxymethamphetamine (MDMA) interacts with therapeutic drugs on CYP3A by inhibition of pregnane X receptor (PXR) activation and catalytic enzyme inhibition.