Journal of Psychosocial Nursing and Mental Health Services
April 1, 2011
Susanne A. Fogger
2 citations
After years of declining use in the United States, youth consumption of ecstasy has increased significantly. Although ecstasy (3, 4-methylenedioxymethamphetamine) is known to be a drug with detrimental effects, users view the drug as a safe and attractive social lubricant. To update and clarify misperceptions, this article reviews current evidence regarding ecstasy's side effects and risks and...
Psychopharmacology
April 1, 2011
Shahaf Edut, Vardit Rubovitch, Shaul Schreiber et al.
36 citations
The use of ecstasy (MDMA) among young adults has dramatically increased over the years. Since MDMA may impair the users' driving ability, the risk of being involved in a motor vehicle accident (MVA) is notably increased. Minimal traumatic brain injury (mTBI) a common consequence of MVAs-produces short- and long-term physical, cognitive, and emotional impairments. To investigate the effects of...
The Journal of Comparative Neurology
March 31, 2011
Csaba Ádori, Rómeó D. Andó, Mária Szekeres et al.
21 citations
3,4-Methylenedioxymethamphetamine (MDMA; ecstasy) is a popular party drug known to cause selective serotonergic damage. Here we examined the long-term recovery and aging of serotonergic fibers and levels of brain-derived neurotrophic factor (BDNF) after intermittent MDMA administration (15 mg kg(-1) i.p. every 7th day for 4 weeks, MDMA ×4) and a single-dose treatment (15 mg kg(-1) i.p., MDMA...
Mitochondrion
March 29, 2011
Orlagh M Kelly, Yvonne M McNamara, Lars H Manzke et al.
Previous researchers have demonstrated that 3,4-methylenedioxymethamphetamine (MDMA) induced hyperthermia, in skeletal muscle of animals, is uncoupling protein 3 (UCP3) dependent. In light of our investigations that in vivo phosphorylation of UCP1 is augmented under conditions of cold-acclimation, we set out to investigate whether (a) UCP3 was phosphorylated in vivo and (b) whether in vivo...
The Open Addiction Journal
March 29, 2011
Jillian Helen Broadbear
1 citation
The Second International MDMA conference in Australasia was held at Monash University in Melbourne on July 18th-19th 2010.Research from over twenty universities was presented, in a program which included both oral papers and posters.The first Australasian MDMA conference was held earlier at the Brain Sciences Institute, Swinburne University, also in Melbourne.All attendees were active MDMA...
The Open Addiction Journal
March 29, 2011
Con Stough
3 citations
The aim of this study was to investigate car driving skills and cognitive abilities after the consumption of methamphetamine and MDMA. In previous studies we have demonstrated significant decrements following sedative drugs such as cannabis, and stimulants such as dexamphetamine. We have also documented the presence of stimulant drugs in many fatal traffic accidents, especially those involving...
The Open Addiction Journal
March 29, 2011
Gillinder Bedi
1 citation
Ecstasy users report that the drug produces feelings of increased empathy and sociability [1]. Such ‘empathogenic’ effects are thought to motivate recreational use of ecstasy [2]. In addition, the rationale for the proposed use of MDMA as an adjunct to psychotherapy centers on these effects [3]. Controlled studies confirm that MDMA administration produces prosocial feelings in humans [e.g. 4],...
The Open Addiction Journal
March 29, 2011
Paul M Anderson
3 citations
Hyperthermia is a key clinical outcome from recreational use of MDMA and is the leading cause of MDMA related hospital admissions as well as being linked to enhanced neurotoxicity [1, 2]. Animal models of ischemia which also display hyperthermia have shown an inflammatory process mediated by microglia and the release of the proinflammatory cytokine interleukin 1(IL-1 ) play a role in...
The Open Addiction Journal
March 29, 2011
Abdallah Salem
1 citation
Project Background The main MDMA-induced adverse effect is disruption of normal thermoregulation leading to life threatening hyperthermia which is exacerbated by high ambient temperature and linked to chronic neurotoxicity. Although the focus of the majority of research on MDMAinduced loss of thermoregulation has been on brain serotonergic and dopaminergic systems, results obtained from our...
The Open Addiction Journal
March 29, 2011
Jillian H. Broadbear
1 citation
are examples of interoceptive cues which enable experienced users to distinguish the effects of MDMA from those of other drugs. Serotonin neurotransmission positively modulates the release of oxytocin into plasma [2]. To test the hypothesis that oxytocin receptor activation contributes to the interoceptive cues of MDMA in male and female rats, two peptidic oxytocin receptor ligands, the agonist...