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The International Journal of Neuropsychopharmacology February 18, 2011
Disruption of prepulse inhibition by 3,4-methylenedioxymethamphetamine (MDMA): comparison between male and female wild-type and 5-HT(1A) receptor knockout mice.
Addiction February 14, 2011 Kate Morefield, Michael Keane, Peter Felgate et al. 83 citations
ABSTRACT Aims To improve our understanding of the pharmacology of ‘ecstasy’ in recreational environments; in particular, to describe the composition of ecstasy pills, patterns of ecstasy use and the relationship between dose of 3,4‐methylendioxymethamphetamine (MDMA) and resulting plasma concentrations. Design, setting and participants A naturalistic observational study of 56 experienced...
Physiology & Behavior February 12, 2011
Adolescent pre-exposure to ethanol or MDMA prolongs the conditioned rewarding effects of MDMA.
Psychopharmacology February 2011 H M Francis, N J Kraushaar, L R Hunt et al.
3,4-Methylenedioxymethamphetamine (MDMA) abuse is a substantial problem in young adults. Due to a high focus on body image in this population, two main factors that may encourage MDMA use are the appetite suppressant and locomotor stimulant effects of this drug. The nucleus accumbens (NAc) is a brain region associated with the regulation of motivated and locomotor behaviours, and recent...
Psychopharmacology February 2011 Marieke M Lansbergen, Glenn Dumont, Joop van Gerven et al.
Typical users of 3,4-methylenedioxymethamphetamine (MDMA or "ecstasy") are polydrug users, combining MDMA with alcohol or cannabis [most active compound: delta-9-tetrahydrocannabinol (THC)]. The aim of the present study was to investigate whether co-administration of alcohol or THC with MDMA differentially affects ongoing electroencephalogram (EEG) oscillations compared to the administration of...
Psychopharmacology February 2011 Csaba Ádori, Péter Low, Rómeó D. Andó et al.
3,4-Methylenedioxymethamphetamine (MDMA, "ecstasy") is a widely used recreational drug known to cause selective long-term serotonergic damage. The aim of this study was to characterize the ultrastructure of serotonergic pericarya and proximal neurites in the dorsal raphe nucleus as well as the ultrastructure of serotonergic axons in the frontal cortex of adolescent Dark Agouti rats 3 days after...
Naunyn-Schmiedeberg's Archives of Pharmacology February 2011 Manuela Di Benedetto, Sussy del Carmen Bastías Candia, Claudio D'Addario et al.
The amphetamine analogue 3,4-methylendioxymetamphetamine (MDMA, Ecstasy) causes complex adaptations at the molecular and cellular levels altering the activity of different brain neurotransmitters. The present study aims to verify the effects of single and repeated injections of MDMA on dynorphin and nociceptin systems gene regulation in the brainstem, an area rich in neurons containing...
Journal of Psychopharmacology January 24, 2011 Jéssica Ruiz‐medina, Catherine Ledent, Olga Carretón et al. 33 citations
Adenosine is an endogenous purine nucleoside that plays a neuromodulatory role in the central nervous system. A2a adenosine receptors have been involved in reward-related processes, inflammatory phenomena and neurotoxicity reactions. In the present study, we investigated the role of A2a adenosine receptors on the acute pharmacological effects, reinforcement and neuroinflammation induced by MDMA...
Biological Chemistry January 2, 2011 Thomas Steinkellner, Michael Freissmuth, Harald H. Sitte et al. 112 citations
Abstract Amphetamine (‘Speed’), methamphetamine (‘Ice’) and its congener 3,4-methylenedioxymethamphetamine (MDMA; ‘Ecstasy’) are illicit drugs abused worldwide for their euphoric and stimulant effects. Despite compelling evidence for chronic MDMA neurotoxicity in animal models, the physiological consequences of such toxicity in humans remain unclear. In addition, distinct differences in the...
cIRcle (University of British Columbia) 2011 Maureen Audrey Moore
This thesis treats the concept of romantic love in relation to women. It attempts to show that the stereotype of romantic love is a fantasy construction which supplies compensation to women who lack status and identity. The qualifier 'romantic' refers to the ecstasy which is thought to occur within the love experience. This ecstasy was present within the concept of courtly love and it has now...